Sellebjerg F, Jensen C V, Christiansen M
Department of Neurology, University of Copenhagen, Glostrup Hospital, 57 Nordre Ringvej, DK-2600 Glostrup, Copenhagen, Denmark.
J Neuroimmunol. 2000 Aug 1;108(1-2):207-15. doi: 10.1016/s0165-5728(00)00292-7.
We studied intrathecal IgG synthesis and autoantibody-secreting cells in 148 patients with possible onset symptoms of MS (POSMS) or clinically definite MS (CDMS). In POSMS intrathecal synthesis of IgG oligoclonal bands and abnormalities on T2-weighted magnetic resonance imaging were associated but the former were more prevalent. The cerebrospinal fluid (CSF) leukocyte count and the number of anti-protelipid protein antibody-secreting cells in cerebrospinal fluid (CSF) correlated with disease activity in POSMS. Intrathecal IgG synthesis levels and the number of anti-myelin basic protein antibody-secreting cells in CSF correlated with disease activity in CDMS. Our results support recent reports of pathogenetic heterogeneity and a pathogenetic role of the antibody response in MS.
我们研究了148例可能患有多发性硬化症起始症状（POSMS）或临床确诊多发性硬化症（CDMS）患者的鞘内IgG合成及自身抗体分泌细胞。在POSMS患者中，IgG寡克隆带的鞘内合成与T2加权磁共振成像异常相关，但前者更为普遍。脑脊液（CSF）白细胞计数及脑脊液中抗蛋白脂蛋白抗体分泌细胞数量与POSMS患者的疾病活动相关。鞘内IgG合成水平及脑脊液中抗髓鞘碱性蛋白抗体分泌细胞数量与CDMS患者的疾病活动相关。我们的结果支持了近期关于多发性硬化症发病机制异质性及抗体反应在发病机制中作用的报道。
