Hastings I M, D'Alessandro U
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK L3 5QA.
Parasitol Today. 2000 Aug;16(8):340-7. doi: 10.1016/s0169-4758(00)01707-5.
The evolution of drug-resistant malaria is one of the most important factors thwarting the development of effective malaria disease control. Several mathematical models have been developed to try and understand the dynamics of this process and how it can be slowed or even avoided. Much of the mathematics describing the evolution of drug resistance in malaria focuses on the derivation and mechanics of the calculations, which can make it inaccessible to experimentalists and field workers. In this article, Ian Hastings and Umberto D'Alessandro describe general model results without recourse to mathematical details, identify the factors that should be considered in the design of drug control programmes, and discuss the crucial parameters that remain unknown and need to be measured in the field or laboratory.
耐药性疟疾的演变是阻碍有效控制疟疾发展的最重要因素之一。已经开发了几种数学模型来试图理解这一过程的动态变化以及如何减缓甚至避免这一过程。许多描述疟疾耐药性演变的数学内容都集中在计算的推导和机制上，这可能使实验人员和现场工作人员难以理解。在本文中，伊恩·黑斯廷斯和翁贝托·达莱桑德罗在不涉及数学细节的情况下描述了一般模型结果，确定了在药物控制计划设计中应考虑的因素，并讨论了仍未知且需要在现场或实验室中测量的关键参数。
