Mettler L, Schirwani D
Am J Obstet Gynecol. 1975 Jan 1;121(1):117-20. doi: 10.1016/0002-9378(75)90986-2.
Cellular sensitization against spermatozoa as antigen was studied in 21 fertile and 41 infertile female subjects. In addition, 20 virgin girls and a group of 11 women presenting positive spermagglutinating (in equal 8) and immobilizing (n equal 3) antibodies were investigated. Cellular sensitization was expressed in terms of macrophage migration inhibitory activity (MIF-reaction). For this screening program washed and pooled spermatozoa (WPS) and sonicated spermatozoa solutions (sss) were used as antigens. In 52 to 72 per cent of all cases, including primary and secondary sterility of unexplained cause, a positive MIF-reaction was encountered. Women with humoral sperm antibodies always revealed a cellular sensitization. Only the group of virgin girls demonstrated in no case a positive MIF-reaction. The need for the identification of the specific fertility-diminishing antigens is stressed as the results indicate a cellular sensitization in all cases that had sperm contact.
在21名有生育能力的女性和41名不孕女性受试者中研究了针对作为抗原的精子的细胞致敏作用。此外，还对20名处女以及一组11名呈现精子凝集抗体阳性（8例）和制动抗体阳性（3例）的女性进行了调查。细胞致敏作用通过巨噬细胞移动抑制活性（MIF反应）来表示。对于这个筛查项目，使用洗涤并汇集的精子（WPS）和超声处理的精子溶液（sss）作为抗原。在所有病例的52%至72%中，包括不明原因的原发性和继发性不育，都出现了阳性MIF反应。有体液性精子抗体的女性总是表现出细胞致敏作用。只有处女组在任何情况下都未表现出阳性MIF反应。强调需要鉴定特定的生育能力降低抗原，因为结果表明所有有精子接触的病例中都存在细胞致敏作用。
