不孕症中针对精子的细胞介导免疫和局部免疫。

Cell mediated and local immunity to spermatozoa in infertility.

作者信息

Dor J, Nebel L A, Soffer Y, Mashiach S, Serr D M

出版信息

Int J Fertil. 1979;24(2):94-100.

Abstract

The possibility of the immunological factor as an etiological cause of infertility was investigated in 50 infertile couples. Of these, 31 couples were considered as an "unexplained sterility" group, while in the other 19 couples a variety of disorders were diagnosed. In vitro, leucocyte migration inhibition test (LMIT) was used for the detection of female cell-mediated immunity against sperm antigens. Sperm immobilization test (SIT) and sperm toxicity tests (STT) were used for the detection of antisperm antibodies in the cervical mucus. Out of the 31 "unexplained sterility" cases, six revealed a positive LMIT (5.3%). In 26 couples with an abnormal postcoital test (PCT), 10 cases had a positive SIT and STT (38.5%). However, out of the group of 16 couples with a normal PCT only in one case was a positive SIT and STT found (6.2%). The potential role of immunological reactions in infertility will be discussed.

摘要

对50对不孕夫妇进行了研究，以探讨免疫因素作为不孕病因的可能性。其中，31对夫妇被归为“不明原因不孕”组，另外19对夫妇被诊断出患有各种疾病。在体外，采用白细胞迁移抑制试验（LMIT）检测女性对精子抗原的细胞介导免疫。采用精子制动试验（SIT）和精子毒性试验（STT）检测宫颈黏液中的抗精子抗体。在31例“不明原因不孕”病例中，6例LMIT呈阳性（5.3%）。在26对性交后试验（PCT）异常的夫妇中，10例SIT和STT呈阳性（38.5%）。然而，在16对PCT正常的夫妇中，仅1例SIT和STT呈阳性（6.2%）。将讨论免疫反应在不孕中的潜在作用。