Dang K, Homko C, Reece E A
Department of Obstetrics/Gynecology and Reproductive Sciences, Temple University School of Medicine, Philadelphia, Pennsylvania 19140-5189, USA.
J Matern Fetal Med. 2000 Mar-Apr;9(2):114-7. doi: 10.1002/(SICI)1520-6661(200003/04)9:2<114::AID-MFM5>3.0.CO;2-R.
To determine whether there is a relationship between birthweight and interval between 1-h and 3-h glucose tolerance test (GTT) as well as other factors.
We performed a retrospective analysis of our computerized diabetes database for the years 1992-1997. Ninety-four women with gestational diabetes fulfilled the inclusion criteria (i.e., singleton gestation, term delivery, absence of medical conditions, and known interval between 1-h and 3-h GTT). They were evaluated based on prepregnancy body mass index (BMI), mean glucose values, interval between diagnostic testing, and gestational age of 3-h GTT.
Subjects with GDM had a mean glucose value of 96.8 mg/dl and average prepregnancy BMI of 29.3 kg/m2. When GDM subjects with and without macrosomic infants were compared, mean glucose values (97.4 vs. 96.6 mg/dl) and mean interval (18.1 vs. 17.0 days) between diagnostic testing did not significantly differ. However, maternal prepregnancy BMI was higher in the group of women who gave birth to macrosomic infants (32.2 vs. 28.22 kg/m2, P = 0.008). Using stepwise multiple regression, maternal prepregnancy BMI was the only variable found to be predictive of macrosomia.
We were unable to show a statistical relationship between interval of diagnostic testing and rate of macrosomia. However, we demonstrated a clear relationship between maternal BMI and infant birthweight.
确定出生体重与1小时和3小时葡萄糖耐量试验（GTT）之间的间隔以及其他因素之间是否存在关联。
我们对1992 - 1997年的计算机化糖尿病数据库进行了回顾性分析。94名患有妊娠期糖尿病的女性符合纳入标准（即单胎妊娠、足月分娩、无疾病状况以及已知1小时和3小时GTT之间的间隔）。根据孕前体重指数（BMI）、平均血糖值、诊断测试之间的间隔以及3小时GTT的孕周对她们进行评估。
患有妊娠期糖尿病的受试者平均血糖值为96.8mg/dl，孕前平均BMI为29.3kg/m²。比较有和没有巨大儿的妊娠期糖尿病受试者时，诊断测试之间的平均血糖值（97.4对96.6mg/dl）和平均间隔（18.1对17.0天）没有显著差异。然而，分娩出巨大儿的女性组孕前BMI更高（32.2对28.22kg/m²，P = 0.008）。使用逐步多元回归分析，发现孕前BMI是唯一可预测巨大儿的变量。
我们未能显示诊断测试间隔与巨大儿发生率之间的统计学关联。然而，我们证明了母亲BMI与婴儿出生体重之间存在明确的关联。
