Demling R H, Salvatierra O, Belzer F O
Arch Surg. 1975 Mar;110(3):251-3. doi: 10.1001/archsurg.1975.01360090021004.
An acute intestinal disorder occurred in seven patients soon after renal transplantation. The disorder was characterized initially by massive abdominal distention with progression to multiple bowel perforations in three patients and extensive bowel necrosis in two. Surgical manipulation did not appear to be the cause since the transplants were performed retroperitoneally in the iliac fossa. Ischemia also was not a factor since the mesenteric vessels were patent with no evidence of thrombus formation or vasculitis. The cause appeared to be related to immunosuppressive agents, in particular, high doses of corticosteroids. The disease process appeared to be reversible if immunosuppression was discontinued early, as occurred in two patients.
7例肾移植患者术后不久发生急性肠道疾病。该疾病最初表现为严重腹胀，3例进展为多处肠穿孔，2例出现广泛肠坏死。手术操作似乎不是病因，因为移植手术是在髂窝腹膜后进行的。缺血也不是一个因素，因为肠系膜血管通畅，没有血栓形成或血管炎的证据。病因似乎与免疫抑制剂有关，特别是高剂量的皮质类固醇。如果早期停用免疫抑制，疾病进程似乎是可逆的，有2例患者就是如此。
