Dunbar S L, Kenney W L
Noll Physiological Research Center and Graduate Program in Physiology, The Pennsylvania State University, University Park, Pennsylvania 16802-6900, USA.
J Appl Physiol (1985). 2000 Jul;89(1):97-103. doi: 10.1152/jappl.2000.89.1.97.
To examine the influence of chronic hormone replacement therapy (HRT) on the central and peripheral cardiovascular responses of postmenopausal women to direct passive heating, seven women taking estrogen replacement therapy, seven women taking estrogen and progesterone therapy, and seven women not taking HRT were passively heated with water-perfused suits to their individual limit of thermal tolerance. Measurements included heart rate (HR), cardiac output, blood pressure, skin blood flow, splanchnic blood flow, renal blood flow, esophageal temperature, and mean skin temperature. Cardiac output was higher in women taking estrogen and progesterone therapy than in women not taking HRT (7.12 +/- 0.70 vs. 5.02 +/- 0. 57 l/min at the limit of thermal tolerance, respectively; P < 0.05) because of a higher HR. However, when the HR data were plotted as a percentage of the maximum HR or percentage of HR reserve, there were no differences among the three groups of women. Neither splanchnic nor renal blood flow differed among the groups of women. These data suggest that HRT has little effect on the cardiovascular responses to direct passive heating.
为研究长期激素替代疗法（HRT）对绝经后女性中枢和外周心血管系统对直接被动加热反应的影响，对7名接受雌激素替代疗法的女性、7名接受雌激素和孕激素疗法的女性以及7名未接受HRT的女性，使用水灌注服将她们被动加热至各自的热耐受极限。测量指标包括心率（HR）、心输出量、血压、皮肤血流量、内脏血流量、肾血流量、食管温度和平均皮肤温度。接受雌激素和孕激素疗法的女性的心输出量高于未接受HRT的女性（分别为热耐受极限时7.12±0.70与5.02±0.57升/分钟；P<0.05），原因是心率较高。然而，当将心率数据绘制为最大心率的百分比或心率储备的百分比时，三组女性之间没有差异。三组女性的内脏血流量和肾血流量均无差异。这些数据表明，HRT对心血管系统对直接被动加热的反应影响很小。
