Tan Y T, Tillett D J, McKay I A
Department of Dermatology, St Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, Centre for Cutaneous Research, 2 Newark Street, London, UK E1 2AT.
Mol Med Today. 2000 Aug;6(8):309-14. doi: 10.1016/s1357-4310(00)01739-1.
Overuse of antibiotics in humans and livestock has led to the rapid evolution of bacteria that are resistant to multiple drugs such that even vancomycin, the drug of last resort, is no longer effective against some strains. Apart from the discovery and exploitation of the natural peptide antimicrobial agents that form part of the innate immune systems of plants and animals, there have been few new antibiotics developed in recent years. Here we review strategies designed to exploit recent advances in molecular biology, including recombinant DNA technology, molecular modelling and genomics to develop new antibacterial agents that overcome antibiotic resistance.
人类和牲畜中抗生素的过度使用导致了对多种药物具有抗性的细菌迅速进化，以至于即使是作为最后手段的万古霉素，对某些菌株也不再有效。除了发现和利用构成动植物先天免疫系统一部分的天然肽抗菌剂外，近年来开发的新抗生素很少。在这里，我们回顾旨在利用分子生物学最新进展的策略，包括重组DNA技术、分子建模和基因组学，以开发克服抗生素耐药性的新型抗菌剂。
