LEPAE, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Portugal.
Nat Prod Rep. 2012 Sep;29(9):1007-21. doi: 10.1039/c2np20035j. Epub 2012 Jul 12.
Infections caused by multidrug-resistant bacteria are an increasing problem due to the emergence and propagation of microbial drug resistance and the lack of development of new antimicrobials. Traditional methods of antibiotic discovery have failed to keep pace with the evolution of resistance. Therefore, new strategies to control bacterial infections are highly desirable. Plant secondary metabolites (phytochemicals) have already demonstrated their potential as antibacterials when used alone and as synergists or potentiators of other antibacterial agents. The use of phytochemical products and plant extracts as resistance-modifying agents (RMAs) represents an increasingly active research topic. Phytochemicals frequently act through different mechanisms than conventional antibiotics and could, therefore be of use in the treatment of resistant bacteria. The therapeutic utility of these products, however, remains to be clinically proven. The aim of this article is to review the advances in in vitro and in vivo studies on the potential chemotherapeutic value of phytochemical products and plant extracts as RMAs to restore the efficacy of antibiotics against resistant pathogenic bacteria. The mode of action of RMAs on the potentiation of antibiotics is also described.
由于微生物耐药性的出现和传播以及新抗菌药物的开发不足，导致多药耐药菌引起的感染成为一个日益严重的问题。传统的抗生素发现方法已经跟不上耐药性的进化速度。因此，非常需要控制细菌感染的新策略。植物次生代谢产物（植物化学物质）已经证明了它们作为单独使用的抗菌剂以及作为其他抗菌剂的增效剂或增强剂的潜力。植物化学物质产品和植物提取物作为耐药性调节剂 (RMA) 的使用代表了一个越来越活跃的研究课题。植物化学物质通常通过与传统抗生素不同的机制发挥作用，因此可用于治疗耐药细菌。然而，这些产品的治疗效果仍有待临床验证。本文的目的是综述植物化学物质产品和植物提取物作为 RMA 恢复抗生素对耐药病原菌疗效的体外和体内研究进展。还描述了 RMA 对增强抗生素作用的作用模式。
