Pharmacognosy Department, Faculty of Pharmacy, MIU, Cairo, Egypt.
Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Nat Prod Res. 2023 Nov-Dec;37(24):4280-4289. doi: 10.1080/14786419.2023.2172009. Epub 2023 Jan 31.
Bacterial resistance to antibiotics poses a high level of danger worldwide. Bacterial resistance mechanisms are spreading globally, impeding our ability to treat common infectious diseases. Misuse and overuse of antibiotics accelerate microbial resistance to antibiotics. Despite the exerted efforts, none of the newly developed antibiotics are expected to be effective against the dangerous forms of antibiotic-resistant bacteria. Since many plants have been shown to contain powerful antimicrobial compounds that can act synergistically or alternatively to antibiotics, the demand for herbal medicines has recently increased to co-treat microbes that are resistant to antibiotics. Maximum benefit can be achieved when the pharmacokinetics and pharmacodynamics of natural products match the antibiotic. This review article refers to nine highly effective and key herbs to use alongside antibiotics to overcome crises of antibiotic resistance. Their unique molecular mechanisms of action have been highlighted.
细菌对抗生素的耐药性在全球范围内构成了高度危险。细菌耐药机制在全球范围内传播，阻碍了我们治疗常见传染病的能力。抗生素的滥用和过度使用加速了微生物对抗生素的耐药性。尽管已经做出了努力，但预计新开发的抗生素中没有一种对危险形式的抗生素耐药细菌有效。由于许多植物已被证明含有强大的抗菌化合物，这些化合物可以与抗生素协同或替代作用，因此最近对抗生素耐药微生物的草药需求增加，以进行联合治疗。当天然产物的药代动力学和药效学与抗生素相匹配时，可获得最大的益处。本文综述了九种与抗生素联合使用以克服抗生素耐药性危机的高效关键草药。强调了它们独特的作用机制。
