Ahringer J
Wellcome CRC Institute, Cambridge, UK.
Trends Genet. 2000 Aug;16(8):351-6. doi: 10.1016/s0168-9525(00)02066-7.
Transcription repression mediated through histone deacetylase (HDAC) complexes is widespread, and mechanisms by which HDAC complexes act have been revealed by extensive studies in vitro and in cell culture. However, until recently, little has been known about the developmental roles of histone deacetylation. Mutants now exist for a number of members of the two major HDAC complexes (NuRD and SIN3) and some associated proteins. The emerging picture is that these complexes have specific functions in development, rather than being required for most cellular processes.
通过组蛋白去乙酰化酶（HDAC）复合物介导的转录抑制作用广泛存在，并且在体外和细胞培养中的大量研究已经揭示了HDAC复合物发挥作用的机制。然而，直到最近，关于组蛋白去乙酰化在发育中的作用仍知之甚少。目前已获得了两种主要HDAC复合物（核小体重塑去乙酰化酶复合物（NuRD）和SIN3复合物）的多个成员以及一些相关蛋白的突变体。新出现的情况是，这些复合物在发育中具有特定功能，而不是大多数细胞过程所必需的。
