Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119992 Moscow, Russia.
Chemistry Department, Lomonosov Moscow State University, 119992 Moscow, Russia.
Int J Mol Sci. 2022 Oct 15;23(20):12341. doi: 10.3390/ijms232012341.
RNA viruses, in pursuit of genome miniaturization, tend to employ cellular proteins to facilitate their replication. HIV-1, one of the most well-studied retroviruses, is not an exception. There is numerous evidence that the exploitation of cellular machinery relies on nucleic acid-protein and protein-protein interactions. Apart from Vpr, Vif, and Nef proteins that are known to regulate cellular functioning via interaction with cell components, another viral protein, integrase, appears to be crucial for proper virus-cell dialog at different stages of the viral life cycle. The goal of this review is to summarize and systematize existing data on known cellular partners of HIV-1 integrase and their role in the HIV-1 life cycle.
RNA 病毒为了追求基因组的小型化，往往会利用细胞蛋白来促进自身的复制。HIV-1 作为研究最为透彻的逆转录病毒之一，也不例外。有大量证据表明，细胞机制的利用依赖于核酸-蛋白和蛋白-蛋白相互作用。除了已知通过与细胞成分相互作用来调节细胞功能的 Vpr、Vif 和 Nef 蛋白外，另一种病毒蛋白整合酶似乎在病毒生命周期的不同阶段对病毒与细胞的正确对话至关重要。本文的目的是总结和系统化 HIV-1 整合酶已知的细胞伙伴及其在 HIV-1 生命周期中的作用的现有数据。
