Taechakraichana N, Intraragsakul A, Panyakhamlerd K, Numchaisrika P, Limpaphayom K
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Med Assoc Thai. 1997 Oct;80(10):626-30.
To assess the changing estradiol (E2) and follicle-stimulating hormone (FSH) level in oophorectomized women using vaginal estrogen. Serum estradiol and FSH were evaluated in 32 oophorectomized women using a daily dose of 2 g base of 1.25 mg vaginal conjugated equine estrogen (CEE) cream. The blood sample for hormone assay was collected 8-10 hours from the time of vaginal application. E2 and FSH levels were measured in the serum sample before and after commencing the study at 4, 8 and 12 weeks using the time-resolved fluoroimmunoassay method. Serum estradiol significantly increased from baseline value at 4, 8 and 12 weeks. (Mean +/- SD of E2 value at 0, 4, 8, 12 weeks: 9.97 +/- 12.13, 249.83 +/- 170.46, 299.38 +/- 190.65, 322.82 +/- 218.31 pmol/L, respectively, P < 0.05) On the other hand, serum FSH significantly decreased from baseline value at 4, 8 and 12 weeks. (Mean +/- SD of FSH value at 0, 4, 8, 12 weeks: 77.64 +/- 27.24, 40.33 +/- 21.64, 38.84 +/- 22.33, 30.90 +/- 24.32 IU/L, respectively, P < 0.05) In conclusion, a daily dose of 2 g vaginal CEE cream raised the serum estradiol level close to the normal level in the follicular phase of the normal menstrual cycle. However, even though FSH significantly decreased it did not reach the premenopausal level.
评估使用阴道雌激素的卵巢切除术后女性体内雌二醇（E2）和促卵泡激素（FSH）水平的变化。对32名卵巢切除术后女性使用每日剂量为2g基质的1.25mg阴道结合马雌激素（CEE）乳膏，并评估其血清雌二醇和FSH水平。在阴道用药8 - 10小时后采集用于激素测定的血样。在研究开始前以及开始后4周、8周和12周，使用时间分辨荧光免疫分析法测定血清样本中的E2和FSH水平。血清雌二醇在4周、8周和12周时较基线值显著升高。（0周、4周、8周、12周时E2值的均值±标准差分别为：9.97±12.13、249.83±170.46、299.38±190.65、322.82±218.31pmol/L，P<0.05）另一方面，血清FSH在4周、8周和12周时较基线值显著降低。（0周、4周、8周、12周时FSH值的均值±标准差分别为：77.64±27.24、40.33±21.64、38.84±22.33、30.90±24.32IU/L，P<0.05）总之，每日剂量为2g的阴道CEE乳膏可使血清雌二醇水平升高至接近正常月经周期卵泡期的正常水平。然而，尽管FSH显著降低，但未达到绝经前水平。
