Limpaphayom K, Taechakraichana N, Kittinunvorakoon C
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Med Assoc Thai. 1997 Mar;80(3):147-52.
Serum follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) was measured in 49 menopausal women, to assess the changing serum level in women with or without hormone replacement. Women in the study group (N = 25) received estrogen with or without progestin. The control group (N = 24) did not receive any hormone regimen. Serum hormone measurement was done at 0, 6 and 12 month, using time-resolved fluoroimmunoassay method. The results revealed no significant change of FSH, LH and E2 at 0, 6 and 12 month in the control group. (FSH at 0, 6, 12 month: 55.14 +/- 22.82, 63.90 +/- 24.54, 72.81 +/- 29.58 IU/L, P = 0.09; LH at 0, 6, 12 month: 35.54 +/- 19.86, 33.02 +/- 16.30, 32.33 +/- 17.37 IU/L, P = 0.83; E2 at 0, 6, 12 month: 49.28 +/- 48.54, 37.29 +/- 39.93, 25.63 +/- 23.58 pmol/L, P = 0.17). However, in the study group, FSH and LH significantly decreased but E2 significantly increased at 6 and 12 months. (FSH at 0, 6, 12 month: 59.33 +/- 22.30, 27.23 +/- 16.31, 29.74 +/- 19.45 IU/L, P < 0.05; LH at 0, 6, 12 months: 41.4 +/- 17.02, 19.62 +/- 13.66, 15.65 +/- 8.77 IU/L, P < 0.05; E2 at 0, 6, 12 months: 47.33 +/- 41.25, 280.94 +/- 174.11, 270.70 +/- 198.65 pmol/L, P < 0.05). In conclusion, hormone replacement decreased serum gonadotrophin, though not reaching the premenopausal level. However, serum E2 value was significantly increased close to the level in the follicular phase of normal menstrual cycle.
对49名绝经后女性测量血清促卵泡生成素（FSH）、促黄体生成素（LH）和雌二醇（E2），以评估接受或未接受激素替代治疗的女性血清水平的变化。研究组（N = 25）的女性接受了雌激素加或不加孕激素治疗。对照组（N = 24）未接受任何激素治疗方案。在0、6和12个月时使用时间分辨荧光免疫分析法进行血清激素测量。结果显示，对照组在0、6和12个月时FSH、LH和E2无显著变化。（0、6、12个月时的FSH：55.14±22.82、63.90±24.54、72.81±29.58 IU/L，P = 0.09；0、6、12个月时的LH：35.54±19.86、33.02±16.30、32.33±17.37 IU/L，P = 0.83；0、6、12个月时的E2：49.28±48.54、37.29±39.93、25.63±23.58 pmol/L，P = 0.17）。然而，在研究组中，FSH和LH在6个月和12个月时显著下降，但E2显著升高。（0、6、12个月时的FSH：59.33±22.30、27.23±16.31、29.74±19.45 IU/L，P < 0.05；0、6、12个月时的LH：41.4±17.02、19.62±13.66、15.65±8.77 IU/L，P < 0.05；0、6、12个月时的E2：47.33±41.25、280.94±174.11、270.70±198.65 pmol/L，P < 0.05）。总之，激素替代治疗降低了血清促性腺激素水平，尽管未达到绝经前水平。然而，血清E2值显著升高，接近正常月经周期卵泡期的水平。
