Gershwin M E, Steinberg A D
Int Arch Allergy Appl Immunol. 1975;48(2):220-4. doi: 10.1159/000231308.
The administration of Concanavalin A (Con A) to young New Zealand (NZB/W) mice has been previously found to render them tolerable to BGG. The corresponding mechanism is unknown but is consistent with other observations that Con A is capable of activating a suppressor T cell population. We have further explored this possibility by giving New Zealand mice Con A from 1 month until 11 months of age and monitoring several known immunologic abnormalities. Con-A-treated mice, in contrast to littermate controls, were found to have lower anti-DNA levels, less proteinuria, a better response to primary sheep red cell immunization and normally rejected skin allografts.
先前发现，给幼年新西兰（NZB/W）小鼠注射伴刀豆球蛋白A（Con A）可使其对牛γ球蛋白（BGG）产生耐受性。相应机制尚不清楚，但与其他观察结果一致，即Con A能够激活抑制性T细胞群体。我们通过在1个月至11个月龄期间给新西兰小鼠注射Con A，并监测几种已知的免疫异常情况，进一步探讨了这种可能性。与同窝对照相比，发现接受Con A治疗的小鼠抗DNA水平较低、蛋白尿较少、对原发性绵羊红细胞免疫的反应较好，并且能够正常排斥同种异体皮肤移植。
