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新西兰黑鼠对绵羊红细胞的长期抗体反应。

The long-term antibody response of New Zealand Black mice to sheep red blood cells.

作者信息

Elkerbout E A, Hijmans W

出版信息

Immunology. 1974 May;26(5):893-900.

Abstract

Long-term IgM and IgG responses to sheep red blood cells (SRBC) were determined in New Zealand Black (NZB) mice, using the plaque technique. As compared with other strains a prolonged spleen plaque-forming cell (PFC) response was found in young and old NZB mice. This phenomenon was found in the primary as well as in the secondary response and concerned IgM as well as IgG production. These observations are discussed in relation to the production of IgG antibodies of a low avidity.

摘要

利用空斑技术测定了新西兰黑鼠(NZB)对绵羊红细胞(SRBC)的长期IgM和IgG反应。与其他品系相比,在年轻和年老的NZB小鼠中均发现脾脏空斑形成细胞(PFC)反应延长。这种现象在初次反应和二次反应中均有发现,且与IgM以及IgG的产生有关。针对低亲和力IgG抗体的产生对这些观察结果进行了讨论。

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