McKay R, McCarty C A, Taylor H R
Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia.
Br J Ophthalmol. 2000 Aug;84(8):865-70. doi: 10.1136/bjo.84.8.865.
To establish the prevalence, severity, and risk factors for diabetic retinopathy in a representative sample of Victorian residents aged 40 years and older.
A population based, cluster sampling method was used to recruit 4744 participants (86% participation rate). Nine randomly selected, suburban Melbourne clusters and four randomly selected, rural Victorian clusters were used. Participants provided a detailed medical and personal history and underwent an ocular examination including funduscopy and fundus photography. Rural participants provided a blood sample, from which the glycosylated haemoglobin percentage was measured. The diagnosis of diabetic retinopathy was based on fundus photographs from participants with self reported diabetes.
The prevalence of diabetic retinopathy among people with self reported diabetes was 29. 1%. The prevalence of untreated, vision threatening retinopathy was 2.8%. Retinopathy was positively associated with a longer reported duration of diabetes diagnosis (p<0.01) and with higher fractions of glycosylated haemoglobin (p<0.01). Retinopathy was not significantly associated with age, ethnicity, body mass index, glaucoma, myopia or intake of alcohol, tobacco, or aspirin (all p > 0.05).
Most people in Victoria with proliferative diabetic retinopathy or clinically significant macular oedema have received laser treatment. There remains however, a small but important group who have not received treatment and whose vision is threatened. People with diabetes should be encouraged to maintain strict glycaemic control and to undergo regular screening to delay or prevent the development of retinopathy.
在维多利亚州40岁及以上居民的代表性样本中确定糖尿病视网膜病变的患病率、严重程度及危险因素。
采用基于人群的整群抽样方法招募4744名参与者(参与率为86%)。使用了9个随机选择的墨尔本郊区群组和4个随机选择的维多利亚州农村群组。参与者提供了详细的病史和个人史,并接受了包括眼底镜检查和眼底摄影在内的眼部检查。农村参与者提供了一份血样,用于测量糖化血红蛋白百分比。糖尿病视网膜病变的诊断基于自我报告患有糖尿病的参与者的眼底照片。
自我报告患有糖尿病的人群中糖尿病视网膜病变的患病率为29.1%。未治疗的、威胁视力的视网膜病变的患病率为2.8%。视网膜病变与报告的糖尿病诊断持续时间较长呈正相关(p<0.01),与糖化血红蛋白比例较高呈正相关(p<0.01)。视网膜病变与年龄、种族、体重指数、青光眼、近视或酒精、烟草或阿司匹林的摄入量均无显著关联(所有p>0.05)。
维多利亚州大多数患有增殖性糖尿病视网膜病变或具有临床意义的黄斑水肿的患者已接受激光治疗。然而,仍有一小部分但很重要的人群未接受治疗,其视力受到威胁。应鼓励糖尿病患者保持严格的血糖控制并定期进行筛查,以延缓或预防视网膜病变的发展。