Radius R L, Anderson D R
Arch Ophthalmol. 1979 Jun;97(6):1154-8. doi: 10.1001/archopht.1979.01020010608021.
By identifying degenerating axons in tissue specimens from 22 primate eyes, it was possible to demonstrate the normal course of axon fibers. Nerve fiber bundles from a group of retinal ganglion cells travel together with little tendency to disperse laterally. In addition, axons are stratified such that processes from more central ganglion cells are successfully added to the inner strata of the retinal nerve fiber layer. Within and behind the lamina cribrosa, areas of degeneration following retinal photocoagulation were well circumscribed and confined to a group of adjacent axon bundles. This degree of retinotopic organization of axons within the nerve head and retinal fiber layer is believed to be consistent with the premise that isolated lesions within the lamina cribrosa could cause well-organized paracentral scotomas such as those characteristic of early glaucoma.
通过识别22只灵长类动物眼睛组织标本中的退化轴突，得以展示轴突纤维的正常走行。一组视网膜神经节细胞的神经纤维束一起走行，几乎没有横向分散的趋势。此外，轴突分层排列，使得来自更中央神经节细胞的突起成功地添加到视网膜神经纤维层的内层。在筛板内和筛板后，视网膜光凝后的退化区域界限清晰，局限于一组相邻的轴突束。神经乳头和视网膜纤维层内轴突的这种视网膜拓扑组织程度被认为与以下前提一致，即筛板内的孤立病变可导致组织良好的旁中心暗点，如早期青光眼的特征性暗点。
