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[抗氧化酶对低剂量辐射诱导的氧化应激的全身反应]

[The systemic response of antioxidant enzymes to the oxidative stress induced by irradiation at low doses].

作者信息

Vartanian L S, Gurevich S M, Kozachenko A I, Nagler L G, Lozovskaia E L, Burlakova E B

机构信息

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow.

出版信息

Radiats Biol Radioecol. 2000 May-Jun;40(3):285-91.

Abstract

As a result of total chronic gamma irradiation of mice (137Cs, 0.6 cGy/day, 9 days) the functioning of superoxide generation and utilisation systems in liver were disturbed. The regulatory links between the activities of superoxide dismutase and glutathione peroxidase are found to be maintained. Postradiation effects were more expressed for a total dose of 1.2 cGy than for a dose of 5.4 cGy, providing support for the hypothesis of delayed reparation as a reason of harmful action of low-dose irradiation.

摘要

对小鼠进行全身慢性γ射线照射(137Cs,0.6 cGy/天,共9天)后,肝脏中超氧化物生成和利用系统的功能受到干扰。超氧化物歧化酶和谷胱甘肽过氧化物酶活性之间的调节联系得以维持。与5.4 cGy剂量相比,1.2 cGy总剂量的辐射后效应更为明显,这为低剂量辐射有害作用的延迟修复假说提供了支持。

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