Kaul S C, Duncan E, Sugihara T, Reddel R R, Mitsui Y, Wadhwa R
National Institute of Bioscience and Human-Technology, AIST, Tsukuba, Ibaraki, Japan.
DNA Res. 2000 Jun 30;7(3):229-31. doi: 10.1093/dnares/7.3.229.
The mouse mortalin proteins Mot-1 and Mot-2 differ by two amino acids in their carboxy-terminus. These proteins are differentially localized in the cell cytoplasm and have contrasting biological activities. The genetic relationship between Mot-1 and Mot-2 was deciphered by mouse family analyses. Mot-1 and Mot-2 segregated in F1 and F2 progeny, providing direct evidence that the two proteins are encoded by two alleles.
小鼠mortalin蛋白Mot-1和Mot-2在其羧基末端相差两个氨基酸。这些蛋白在细胞质中定位不同，并具有相反的生物学活性。通过小鼠家族分析解析了Mot-1和Mot-2之间的遗传关系。Mot-1和Mot-2在F1和F2后代中分离，提供了这两种蛋白由两个等位基因编码的直接证据。
