Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka, 821-8582, Japan.
Gastric Cancer. 2014 Apr;17(2):255-62. doi: 10.1007/s10120-013-0279-1. Epub 2013 Jul 5.
Mortalin is a heat-non-inducible member of the heat shock protein 70 family. Mortalin binds to p53 and prevents p53 from entering the nucleus. To understand the significance of mortalin in gastric cancer, we investigated the expression of mortalin and p53.
Expression of mortalin and p53 was examined by immunohistochemical staining of 182 clinical samples of gastric cancer.
Mortalin-positive and aberrant p53-positive tumors were found in 75.2 and 49.5 % of cases, respectively. Mortalin-positive tumors were deeper in invasion and had more lymph node and liver metastases compared with mortalin-negative tumors (P < 0.01, P < 0.05, respectively). Mortalin-positive tumors had worse prognosis compared with mortalin-negative tumors (P = 0.035). Moreover, in tumors with normal p53 function, mortalin-positive tumors had worse prognosis compared with mortalin-negative tumors (P = 0.017).
Mortalin has a great impact on gastric cancer with normal p53. Therefore, mortalin is a target molecule for treatment of gastric cancer, as well as a promising prognostic factor, especially in tumors with normal p53.
线粒体蛋白是热休克蛋白 70 家族中一种热非诱导成员。线粒体蛋白与 p53 结合，阻止 p53 进入细胞核。为了了解线粒体蛋白在胃癌中的意义，我们研究了线粒体蛋白和 p53 的表达。
通过对 182 例胃癌临床样本的免疫组织化学染色，检测线粒体蛋白和 p53 的表达。
分别有 75.2%和 49.5%的病例出现线粒体蛋白阳性和异常 p53 阳性肿瘤。与线粒体蛋白阴性肿瘤相比，线粒体蛋白阳性肿瘤浸润更深，淋巴结和肝转移更多（P<0.01，P<0.05）。与线粒体蛋白阴性肿瘤相比，线粒体蛋白阳性肿瘤的预后较差（P=0.035）。此外，在 p53 功能正常的肿瘤中，线粒体蛋白阳性肿瘤的预后较线粒体蛋白阴性肿瘤差（P=0.017）。
线粒体蛋白对 p53 正常的胃癌有很大影响。因此，线粒体蛋白是胃癌治疗的靶分子，也是一个有前途的预后因素，特别是在 p53 正常的肿瘤中。
