Vento S I, Wolff C H, Salven P J, Hytönen M L, Ertama L O, Malmberg C H
Department of Otorhinolaryngology, Helsinki University Central Hospital, Finland.
Acta Otolaryngol Suppl. 2000;543:170-4. doi: 10.1080/000164800454314.
Although the aetiology of polyps is still, for the most part, unknown, the disease is known to involve tissue oedema. Vascular permeability/vascular endothelial growth factor (VPF/VEGF) is a major inducer of angiogenesis and capillary permeability. This study investigated VPF/VEGF expression in biopsies of nasal polyps from 39 patients and in healthy nasal mucosa from 10 patients by immunohistochemical staining. Staining for VPF/VEGF in the mucosal surface and in the glandular epithelium of nasal polyps was weaker than in normal controls. In two patients, strong staining for VPF/VEGF was found in a granular pattern in mast cells, while the mast cells in other polyposis patients appeared to be largely degranulated. VPF/VEGF was not seen in the mast cells of control patients. Although expression of VPF/VEGF was not increased in the epithelium of the nasal polyps, VPF/VEGF secreted from mast cells may take part in nasal polyp formation.
尽管息肉的病因在很大程度上仍不明确，但已知该疾病涉及组织水肿。血管通透性/血管内皮生长因子（VPF/VEGF）是血管生成和毛细血管通透性的主要诱导因子。本研究通过免疫组织化学染色，对39例鼻息肉患者的活检组织以及10例健康鼻黏膜组织中的VPF/VEGF表达情况进行了调查。鼻息肉黏膜表面和腺上皮中VPF/VEGF的染色比正常对照组弱。在两名患者中，肥大细胞中发现VPF/VEGF呈颗粒状强染色，而其他息肉病患者的肥大细胞似乎大多已脱颗粒。对照组患者的肥大细胞中未发现VPF/VEGF。尽管鼻息肉上皮中VPF/VEGF的表达没有增加，但肥大细胞分泌的VPF/VEGF可能参与鼻息肉的形成。
