知母中分离出的活性化合物尼亚醇与唑类药物对白色念珠菌的体外协同作用。

In vitro synergism between nyasol, an active compound isolated from Anemarrhena asphodeloides, and azole agents against Candida albicans.

作者信息

Iida Y, Oh K B, Saito M, Matsuoka H, Kurata H

机构信息

Department of Biotechnology, Faculty of Technology, Tokyo University of Agriculture and Technology, Japan.

出版信息

Planta Med. 2000 Jun;66(5):435-8. doi: 10.1055/s-2000-8589.

DOI:10.1055/s-2000-8589

PMID:10909263

Abstract

The antifungal activity of nyasol (NYS) alone or with various antifungal agents was measured in vitro against Candida albicans, Aspergillus fumigatus, and Trichophyton mentagrophytes. NYS is a compound recently purified from a medicinal plant, Anemarrhena asphodeloides. Among 12 agents, miconazole (MCZ), ketoconazole (KCZ), clotrimazole (CTZ), and cerulenin showed marked synergistic effects against C. albicans. The fractional inhibition concentration (FIC) indices against 4 strains of C. albicans were 0.067-0.31 for MCZ plus NYS, 0.078-0.31 for KCZ plus NYS, and 0.098-0.13 for CTZ plus NYS. These values indicate the possibility of using NYS as an adjuvant to azole agents in the chemotherapy of candidiasis.

摘要

单独或与各种抗真菌剂联合使用时，测定了尼亚索尔（NYS）对白色念珠菌、烟曲霉和须癣毛癣菌的体外抗真菌活性。NYS是最近从药用植物知母中纯化得到的一种化合物。在12种药物中，咪康唑（MCZ）、酮康唑（KCZ）、克霉唑（CTZ）和浅蓝菌素对白色念珠菌表现出显著的协同作用。MCZ加NYS对4株白色念珠菌的部分抑制浓度（FIC）指数为0.067 - 0.31，KCZ加NYS为0.078 - 0.31，CTZ加NYS为0.098 - 0.13。这些值表明在念珠菌病化疗中使用NYS作为唑类药物佐剂的可能性。