McKnight J A, Mauldin G N, McEntee M C, Meleo K A, Patnaik A K
Animal Medical Center, New York, NY 10021, USA.
J Am Vet Med Assoc. 2000 Jul 15;217(2):205-10. doi: 10.2460/javma.2000.217.205.
To evaluate efficacy of radiation for treatment of incompletely resected soft-tissue sarcomas in dogs.
Prospective serial study.
48 dogs with soft-tissue sarcomas.
Tumors were resected to < 3 cm3 prior to radiation. Tumors were treated on alternate days (three 3-Gy fractions/wk) until 21 fractions had been administered. Cobalt 60 radiation was used for all treatments.
Five-year survival rate was 76%, and survival rate was not different among tumor types or locations. Four (8%) dogs developed metastases. Eight (17%) dogs had tumor recurrence after radiation. Development of metastases and local recurrence were significantly associated with reduced survival rate. Median survival time in dogs that developed metastases was 250 days. Median disease-free interval for all dogs was 1,082 days. Median time to recurrence was 700 days. Dogs that developed recurrence after a prolonged period responded well to a second surgery. Acute radiation toxicosis was minimal; osteosarcoma developed at the radiation site in 1 dog.
An excellent long-term survival rate may be achieved by treating soft-tissue sarcomas in dogs with resection followed by radiation. Amputation is not necessary for long-term control of soft-tissue sarcomas in limbs. Development of metastases and recurrence of local tumors after radiation treatment are associated with decreased survival rate. Acute and delayed radiation toxicosis was minimal with the protocol used in this study.
评估放射治疗犬不完全切除软组织肉瘤的疗效。
前瞻性系列研究。
48只患有软组织肉瘤的犬。
放疗前将肿瘤切除至体积小于3 cm³。肿瘤每隔一天接受治疗（每周3次，每次3 Gy），直至给予21次照射。所有治疗均使用钴60放疗。
五年生存率为76%，不同肿瘤类型和部位的生存率无差异。4只（8%）犬发生转移。8只（17%）犬放疗后肿瘤复发。转移和局部复发的发生与生存率降低显著相关。发生转移的犬的中位生存时间为250天。所有犬的中位无病间期为1082天。中位复发时间为700天。长时间后复发的犬对二次手术反应良好。急性放射中毒轻微；1只犬在放疗部位发生骨肉瘤。
对犬软组织肉瘤进行切除后放疗可获得优异的长期生存率。肢体软组织肉瘤的长期控制无需截肢。放疗后转移的发生和局部肿瘤的复发与生存率降低相关。本研究使用的方案急性和迟发性放射中毒轻微。
