1NorthStar VETS, Robbinsville, NJ.
3Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
J Am Vet Med Assoc. 2023 Jul 12;261(10):1-8. doi: 10.2460/javma.23.02.0119. Print 2023 Oct 1.
To evaluate the outcome and effects of single high-dose radiation therapy with the aid of liquid fiducial markers in dogs following resection of soft tissue sarcomas (STSs).
36 client-owned dogs.
Dogs with a histologic diagnosis of a grade II or III STS that underwent liquid fiducial guided single fraction, 20-Gy stereotactic radiation therapy following surgical excision of an STS between May 2017 and March 2019 were prospectively enrolled in this study. Data collected from the medical records included patient signalment, tumor-related information, treatment details, and outcome. Kaplan-Meier survival analysis was performed for overall survival time (OST) and disease-free interval (DFI). The median OST and DFI were not reached, so restricted mean OST and DFI were also calculated.
36 dogs were included in the study. All dogs underwent radiation therapy a mean of 36.1 days (range, 20 to 59 days) after surgery. Acute and delayed radiation toxicity effects occurred in 80.5% and 36.1% of dogs, respectively, all of which affected the skin. Tumor recurrence was noted in 24.3% of dogs with a median time to recurrence of 272 days (range, 14 to 843 days). The restricted mean OST was 1,556 days (range, 1,383 to 1,728 days) and restricted mean DFI was 1,330 days (range, 1,101 to 1,559 days).
The results of this study showed that administering a single 20-Gy fraction of radiation in combination with a liquid fiducial marker to treat marginally or incompletely resected STS in the absence of gross disease resulted in similar OST and DFI compared to other previously reported radiation protocols.
评估在软组织肉瘤（STS）切除术后，使用液体基准标记物辅助单次高剂量放疗的结果和影响。
36 只患犬。
2017 年 5 月至 2019 年 3 月期间，对组织学诊断为 II 级或 III 级 STS 并接受液体基准引导的单次 20-Gy 立体定向放疗的 STS 手术后的 36 只患犬进行前瞻性研究。从病历中收集的数据包括患者特征、肿瘤相关信息、治疗细节和结果。进行 Kaplan-Meier 生存分析以评估总生存时间（OS）和无病间隔（DFI）。未达到中位 OST 和 DFI，因此还计算了受限平均 OST 和 DFI。
36 只犬纳入研究。所有犬均在手术后平均 36.1 天（范围为 20 至 59 天）进行放疗。分别有 80.5%和 36.1%的犬发生急性和迟发性放射毒性效应，均影响皮肤。24.3%的犬出现肿瘤复发，中位复发时间为 272 天（范围为 14 至 843 天）。受限平均 OST 为 1556 天（范围为 1383 至 1728 天），受限平均 DFI 为 1330 天（范围为 1101 至 1559 天）。
本研究结果表明，对于边缘或不完全切除的 STS，在无明显疾病的情况下，单次给予 20-Gy 剂量的放疗联合液体基准标记物，与其他先前报道的放疗方案相比，具有相似的 OST 和 DFI。
