Musial F, Musial A, Kalveram K T, Enck P, Crowell M D
Dept. of General Psychology, Heinrich-Heine-University, Düsseldorf, Germany.
Folia Med Cracov. 1999;40(3-4):107-14.
Interactions between visceral, intestinal stimulation and autonomic cardiovascular function have received increasing attention over the last years. The aim of the study was to investigate the effect of long-term continuous rectal distention on rectal tone and cardiovascular function at the threshold for first sensation of distention and moderate urge to defecate compared to a resting period without distention. Continuous isobaric rectal distention was performed in 13 healthy volunteers with a ten minute pressure tracking procedure at each subject's predetermined individual threshold for either moderate urge or first sensation, separated by a ten minute resting period. Rectal volume, heart rate, systolic and diastolic blood pressure were determined continuously.
Rectal tone decreased significantly over time at the threshold for moderate urge and first sensation. Cardiovascular measures remained stable over the distention procedures, except for a significant increase in systolic blood pressure at the threshold for moderate urge.
The previously reported rectal accommodation response to rectal distention was confirmed. The increase in systolic blood pressure is most likely mediated through sympathetic efferent pathways.
在过去几年中，内脏、肠道刺激与自主心血管功能之间的相互作用受到了越来越多的关注。本研究的目的是，与无扩张的静息期相比，研究在首次感觉到扩张和有适度排便冲动的阈值下，长期持续直肠扩张对直肠张力和心血管功能的影响。对13名健康志愿者进行等压直肠持续扩张，在每个受试者预先确定的适度冲动或首次感觉的个体阈值下进行10分钟的压力跟踪程序，中间间隔10分钟的静息期。连续测定直肠容积、心率、收缩压和舒张压。
在适度冲动和首次感觉的阈值下，直肠张力随时间显著下降。除了在适度冲动阈值下收缩压显著升高外，心血管指标在扩张过程中保持稳定。
先前报道的直肠对直肠扩张的适应性反应得到了证实。收缩压的升高很可能是通过交感传出通路介导的。
