Malcolm A, Phillips S F, Camilleri M, Hanson R B
Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA.
Am J Gastroenterol. 1997 Nov;92(11):2073-9.
Drugs can alter perception of balloon distention of the GI tract. It has been proposed that the mechanism by which this occurs is through effects on visceral afferent pathways. Our hypothesis was that modulation of rectal tone will also influence the perception of rectal balloon distention.
Fasting and postprandial rectal tone, compliance, and perception of rectal distention were measured in 25 healthy subjects, using a five-armed, parallel, single-blinded study design. Each subject received either glucagon, nitroglycerin, clonidine, yohimbine, or saline.
Rectal tone, but not compliance, influenced perception as measured by balloon distention of the rectum (r = 0.6, p = 0.002). Glucagon, nitroglycerin, and clonidine reduced and yohimbine increased fasting tone compared with saline. Compliance and postprandial tone were similar in all groups. Yohimbine increased rectal perception of distention.
Tone is one of the factors that influences the sensory perception of balloon distention in the human rectum. Alpha2-adrenergic agents, a nitric oxide donor, and glucagon altered fasting rectal tone, but postprandial tone was similar after administration of each agent.
药物可改变胃肠道气球扩张的感知。有人提出，其发生机制是通过对内脏传入通路的影响。我们的假设是，直肠张力的调节也会影响直肠气球扩张的感知。
采用五臂、平行、单盲研究设计，对25名健康受试者测量空腹和餐后直肠张力、顺应性以及直肠扩张的感知。每位受试者接受胰高血糖素、硝酸甘油、可乐定、育亨宾或生理盐水。
如通过直肠气球扩张测量，直肠张力而非顺应性影响感知（r = 0.6，p = 0.002）。与生理盐水相比，胰高血糖素、硝酸甘油和可乐定降低空腹张力，育亨宾增加空腹张力。所有组的顺应性和餐后张力相似。育亨宾增加直肠扩张的感知。
张力是影响人类直肠气球扩张感觉感知的因素之一。α2-肾上腺素能药物、一氧化氮供体和胰高血糖素改变空腹直肠张力，但各药物给药后餐后张力相似。
