Sloots Cornelius E J, Felt-Bersma Richelle J F, West Rachel L, Kuipers Ernst J
Department of Gastroenterology and Hepatology, Erasmus Medical Centre, Rotterdam.
Scand J Gastroenterol. 2005 Jul;40(7):808-13. doi: 10.1080/00365520510015872.
Coffee and cigarette use is believed to induce bowel movements, although the literature is controversial and precise measurements of rectal tone and sensitivity with a barostat have never been performed. The aim of this study was to assess the effects of coffee and nicotine on rectal tone, compliance and sensitivity.
Sixteen healthy volunteers were recruited for the coffee (n = 8) and nicotine (n = 8) experiments. The experiments were randomly performed in a placebo-controlled crossover design on separate days. In the coffee experiment, 280 ml strong coffee or warm water was drunk and in the nicotine experiment, nicotine (2 mg) or placebo was given sublingually. A rectal barostat procedure was carried out. A flaccid bag, mounted on a catheter, was inserted in the rectum. Continuous pressure distension was exerted to register basal visceral sensitivity and compliance. After rectal adaptation, the stimulus was given. Rectal tone was measured for 1 h, after which continuous pressure distension was repeated.
Rectal tone increased by 45% 30 min after coffee intake (p = 0.031) and by 30% after water intake (p = 0.032), but the effects of coffee and water were not significantly different. Rectal tone did not change significantly after administration of nicotine (7%) or placebo (10%). There was no difference in compliance and visceral sensitivity between coffee and water or nicotine and placebo.
Both coffee and warm water have an effect on defecation by increasing rectal tone, but nicotine (2 mg) did not affect rectal tone. Coffee and nicotine did not influence sensitivity or compliance.
尽管文献存在争议且从未使用恒压器对直肠张力和敏感性进行精确测量，但人们认为咖啡和吸烟会促进排便。本研究的目的是评估咖啡和尼古丁对直肠张力、顺应性和敏感性的影响。
招募了16名健康志愿者进行咖啡（n = 8）和尼古丁（n = 8）实验。实验采用安慰剂对照交叉设计，在不同日期随机进行。在咖啡实验中，饮用280毫升浓咖啡或温水；在尼古丁实验中，舌下给予尼古丁（2毫克）或安慰剂。进行直肠恒压器检查。将一个安装在导管上的松弛袋子插入直肠。施加持续的压力扩张以记录基础内脏敏感性和顺应性。直肠适应后，给予刺激。测量直肠张力1小时，之后重复持续的压力扩张。
摄入咖啡后30分钟直肠张力增加45%（p = 0.031），摄入水后增加30%（p = 0.032），但咖啡和水的作用无显著差异。给予尼古丁（7%）或安慰剂（10%）后直肠张力无显著变化。咖啡与水或尼古丁与安慰剂之间在顺应性和内脏敏感性方面无差异。
咖啡和温水均通过增加直肠张力对排便产生影响，但尼古丁（2毫克）不影响直肠张力。咖啡和尼古丁不影响敏感性或顺应性。
