Cahana A, Shvelzon V, Dolberg O, Magora F, Shir Y
Pain Treatment Services, Dept. of Anesthesiology of Sheba Medical Center, University Hospital, Jerusalem.
Harefuah. 1998 May 1;134(9):692-4, 751, 750.
Intravenous injection of lignocaine relieves pain in animals with experimentally induced pain, and in man, mainly those with neuropathic pain. 106 patients were treated with intravenous lignocaine during a period of 18 months (212 treatment sessions). Blood pressure, heart rate and pain scores were continuously monitored after an intravenous bolus of lignocaine, 1 mg/kg, followed by continuous infusion of lignocaine, 5 mg/kg during 1 hour. There was significant pain relief after each session in most patients, lasting from a few hours to 4 weeks. There were no significant side effects. We present 2 of our patients. Due to its simplicity, efficacy and safety, intravenous lignocaine injection is recommended for those with neuropathic pain unrelieved by other therapeutic modalities.
静脉注射利多卡因可缓解实验性诱导疼痛动物以及人类(主要是神经性疼痛患者)的疼痛。在18个月期间(212次治疗疗程),对106例患者进行了静脉注射利多卡因治疗。静脉推注1mg/kg利多卡因后,持续监测血压、心率和疼痛评分,随后在1小时内持续输注5mg/kg利多卡因。大多数患者在每次疗程后疼痛均有显著缓解,持续时间从数小时至4周不等。未出现明显副作用。我们展示2例患者。由于静脉注射利多卡因操作简单、疗效确切且安全,推荐用于经其他治疗方式无法缓解的神经性疼痛患者。