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从多微生物性肝脓肿中分离出腐蚀艾肯菌:1例报告

Isolation of Eikenella corrodens from polymicrobial hepatic abscess: report of one case.

作者信息

Chang P S, Ni Y H, Lin W T, Lee C Y, Chang M H

机构信息

Department of Pediatrics, National Taiwan University Hospital, Taipei.

出版信息

Acta Paediatr Taiwan. 1999 Jan-Feb;40(1):50-2.

Abstract

Eikenella corrodens is a rare cause of hepatic abscess. We report a case of a hepatic abscess caused by (1) Bacteroides fragilis, (2) Streptococcus constellatus and (3) E. corrodens, which illustrates potential problems of antibiotic coverage due to the presence of Eikenella species. The infection followed an episode of acute gastroenteritis and the clinical course appeared indolent evolving over one week. Besides empirical antibiotics, initial percutaneous aspiration was performed and yielded pus which grew E. corrodens concomitantly with Streptococcus species. E. corrodens was sensitive to penicillin but resistant to clindamycin and metronidazole. But B. fragilis was resistant to penicillin. So the antibiotics were switched to amoxicillin/clavulanate. Unfortunately fever persisted and the abscess increased in size. Therefore echo-guided percutaneous drainage with pigtail catheter was installed. Fever subsided 5 days later. After 21 days treatment of antibiotics, the patient was discharged in good condition despite having some sterile fluid in the residual abscess cavity. Two months after discharge the follow-up echogram confirmed complete resolution of the residual abscess. This patient shows us the existence of E. corrodens in pediatric patients, especially when the hepatic abscess is very likely from the spread of an oral or abdominal infection.

摘要

腐蚀埃肯菌是肝脓肿的罕见病因。我们报告一例由(1)脆弱拟杆菌、(2)星座链球菌和(3)腐蚀埃肯菌引起的肝脓肿病例,该病例说明了由于存在埃肯菌属而导致抗生素覆盖的潜在问题。感染发生在一次急性肠胃炎发作之后,临床病程呈隐匿性发展,持续了一周。除了经验性使用抗生素外,最初还进行了经皮穿刺抽吸,抽出的脓液培养出了腐蚀埃肯菌和链球菌。腐蚀埃肯菌对青霉素敏感,但对克林霉素和甲硝唑耐药。而脆弱拟杆菌对青霉素耐药。因此将抗生素换成了阿莫西林/克拉维酸盐。不幸的是,发热持续,脓肿增大。于是安装了经超声引导的猪尾导管经皮引流。5天后发热消退。经过21天的抗生素治疗,尽管残留脓肿腔内有一些无菌液体,患者仍状况良好地出院。出院两个月后的随访超声检查证实残留脓肿已完全消退。该患者向我们展示了儿科患者中存在腐蚀埃肯菌的情况,尤其是当肝脓肿很可能是由口腔或腹部感染蔓延所致时。

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