系统性红斑狼疮的分子发病机制
Molecular pathogenesis of systemic lupus erythematosus.
作者信息
Alekberova Z S, Parfanovich M I, Nasonova V A, Zhdanov V M
出版信息
Arch Virol. 1975;47(2):109-21. doi: 10.1007/BF01320551.
Abstract
The study of patients with systemic lupus erythematosus revealed the close association of the disease with measles--or a related virus. High titres of antibodies to measles virus were found in patients that correlated with the course of the disease. Immunofluorescence tests revealed measles virus or a related antigen in lupus-affected tissues. Inclusion bodies consisting of paramyxovirus-like ribonucleoprotein structures were regularly detected in both affected tissues and leukocytes. Molecular hybridization of measles virus RNA with DNA from the affected tissues showed that DNA transcripts of measles or a closely related virus are integrated in the cellular nuclear DNA. Possible pathogenetic mechanisms of the disease are discussed.
摘要
对系统性红斑狼疮患者的研究揭示了该疾病与麻疹——或一种相关病毒之间的密切关联。在患者体内发现了高滴度的抗麻疹病毒抗体，这些抗体与疾病进程相关。免疫荧光试验在狼疮受累组织中发现了麻疹病毒或一种相关抗原。在受累组织和白细胞中均定期检测到由副粘病毒样核糖核蛋白结构组成的包涵体。麻疹病毒RNA与受累组织DNA的分子杂交表明，麻疹或一种密切相关病毒的DNA转录本整合在细胞核DNA中。文中讨论了该疾病可能的发病机制。
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引用本文的文献
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