Hegedüs V M, Schramm-Thiel N, Wacker A
Arzneimittelforschung. 1975 Feb;25(2):222-3.
The Jerne technique, a proved method for detecting the number of plaque-forming cells (PFC) in spleen, shows an immunosuppressive effect of phytohemagglutine (PHA) on primary immune response. Kinetic studies are done on 300 NMRI mice, considering the number of PFC/10-8 spleen cells. Significant suppressions of the primary immune response are found if PHA is applied either one day before or together with antigen provided that studies are done 3, 4 or 5 days after immunization with sheep red blood cells (SRBC). The role of activated T-lymphocytes concerning the diminution of immune response is discussed.
耶尔恩技术是一种已被证实的检测脾脏中斑块形成细胞（PFC）数量的方法，它显示了植物血凝素（PHA）对初次免疫反应的免疫抑制作用。对300只NMRI小鼠进行了动力学研究，以PFC/10-8脾细胞数量为指标。如果在免疫绵羊红细胞（SRBC）后3、4或5天进行研究，发现若在抗原接种前一天或与抗原同时应用PHA，会对初次免疫反应产生显著抑制。文中还讨论了活化T淋巴细胞在免疫反应减弱方面的作用。
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