Ernström U, Söder O
Clin Exp Immunol. 1975 Jul;21(1):131-40.
Plaque-forming cells (PFC) and rosette-forming cells (RFC) were quantificated in splenic venous and splenic arterial blood and in spleen suspensions of guinea-pigs during a secondary immune response to sheep red blood cells (SRBC). The splenic veno-arterial differences in content of PFC and RFC were determined, indicating whether there had been a release of such cells from the spleen into the blood. The effect of an intracardial injection of adrenaline on the release of immune lymphocytes was investigated. In immunized control animals a splenic release of antigen-binding and antibody-forming cells was found, the release being restricted to the peak of the immune response in the spleen. However, after exogenous adrenaline a considerably increased release of both antigen-binding and antibody-forming cells occurred during a longer period of the immune response. Thus, adrenaline caused an enormous release of PFC from the spleen into the blood on day 4 of the secondary immune response, resulting in a diminished number of PFC remaining in the spleen after the treatment. A physiological significance of an adrenaline-induced dissemination of immune lymphocytes in the body during an immune response to a severe infectious disease is suggested.
在豚鼠对绵羊红细胞（SRBC）的二次免疫反应期间，对脾静脉血、脾动脉血以及脾脏悬液中的空斑形成细胞（PFC）和玫瑰花结形成细胞（RFC）进行了定量分析。测定了PFC和RFC含量在脾静脉与脾动脉之间的差异，以表明此类细胞是否从脾脏释放到血液中。研究了心内注射肾上腺素对免疫淋巴细胞释放的影响。在免疫对照动物中，发现脾脏释放抗原结合细胞和抗体形成细胞，这种释放仅限于脾脏免疫反应的高峰期。然而，在外源性肾上腺素作用后，在免疫反应的较长时间段内，抗原结合细胞和抗体形成细胞的释放均显著增加。因此，肾上腺素在二次免疫反应的第4天导致大量PFC从脾脏释放到血液中，使得处理后脾脏中剩余的PFC数量减少。提示了肾上腺素诱导的免疫淋巴细胞在机体中的播散在对严重传染病的免疫反应中的生理意义。
