Thong F S, Hudson R, Ross R, Janssen I, Graham T E
Department of Human Biology and Nutritional Sciences, University of Guelph, N1G 2W1, Kingston, Ontario, Canada K7L 3N6.
Am J Physiol Endocrinol Metab. 2000 Aug;279(2):E307-13. doi: 10.1152/ajpendo.2000.279.2.E307.
The independent effects of weight loss and exercise on plasma leptin and total (AT), subcutaneous (SAT), and visceral (VAT) adipose tissue were investigated in 52 obese men. Subjects were randomly assigned to four 12-wk protocols: 1) control (C, n = 8), 2) diet-induced weight loss (DWL, n = 14), 3) exercise-induced weight loss (EWL, n = 14), and 4) exercise with weight maintenance (EWS, n = 16). Plasma leptin was unchanged in C (from 7.8 +/- 1.3 to 7.7 +/- 1.0 ng/ml). Equivalent weight loss (7.5 kg) decreased leptin significantly but similarly (DWL, from 8.5 +/- 1.0 to 4.8 +/- 0.6 ng/ml; EWL, from 10.1 +/- 1.0 to 5.0 +/- 0.6 ng/ml). Exercise in the absence of weight loss did not alter leptin levels (from 10.1 +/- 1. 3 to 9.2 +/- 1.2 ng/ml). Changes in leptin correlated with changes in AT and SAT (both P < 0.05) but not in VAT. We conclude that reduction in adipose tissue after weight loss results in a collateral decrease in circulating leptin, and exercise, independent of its effects on weight loss, has no profound influence on leptin secretion.
在52名肥胖男性中研究了体重减轻和运动对血浆瘦素以及总脂肪组织（AT）、皮下脂肪组织（SAT）和内脏脂肪组织（VAT）的独立影响。受试者被随机分配到四个为期12周的方案中：1）对照组（C，n = 8），2）饮食诱导体重减轻组（DWL，n = 14），3）运动诱导体重减轻组（EWL，n = 14），4）运动但体重维持组（EWS，n = 16）。C组血浆瘦素无变化（从7.8±1.3降至7.7±1.0 ng/ml）。同等程度的体重减轻（7.5 kg）显著降低了瘦素水平，但降低程度相似（DWL组，从8.5±1.0降至4.8±0.6 ng/ml；EWL组，从10.1±1.0降至5.0±0.6 ng/ml）。无体重减轻情况下的运动未改变瘦素水平（从10.1±1.3降至9.2±1.2 ng/ml）。瘦素的变化与AT和SAT的变化相关（均P<0.05），但与VAT的变化无关。我们得出结论，体重减轻后脂肪组织减少导致循环瘦素随之减少，并且运动，无论其对体重减轻的影响如何，对瘦素分泌均无深远影响。
