Grasso Patricia
Department of Medicine, Albany Medical College, Albany, NY, United States.
Department of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, NY, United States.
Front Aging Neurosci. 2022 Apr 22;14:861350. doi: 10.3389/fnagi.2022.861350. eCollection 2022.
In this review, the current understanding of leptin's role in energy balance, glycemic regulation, and cognitive function is examined, and its involvement in maintaining the homeostatic "harmony" of these physiologies is explored. The effects of exercise on circulating leptin levels are summarized, and the results of clinical application of leptin to metabolic disease and neurologic dysfunction are reviewed. Finally, pre-clinical evidence is presented which suggests that synthetic peptide leptin mimetics may be useful in resolving not only the leptin resistance associated with common obesity and other elements of metabolic syndrome, but also the peripheral insulin resistance characterizing type 2 diabetes mellitus, and the central insulin resistance associated with certain neurologic deficits in humans.
在本综述中，我们研究了目前对瘦素在能量平衡、血糖调节和认知功能中作用的理解，并探讨了其在维持这些生理功能的稳态“和谐”中的作用。总结了运动对循环瘦素水平的影响，并回顾了瘦素在代谢疾病和神经功能障碍临床应用的结果。最后，给出了临床前证据，表明合成肽瘦素模拟物不仅可能有助于解决与常见肥胖和代谢综合征其他因素相关的瘦素抵抗，还可能有助于解决2型糖尿病特征性的外周胰岛素抵抗，以及与人类某些神经功能缺损相关的中枢胰岛素抵抗。
