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大肠杆菌的yiaR和yiaS基因在内源性生成的L-木酮糖代谢中的作用。

Role of the yiaR and yiaS genes of Escherichia coli in metabolism of endogenously formed L-xylulose.

作者信息

Ibañez E, Gimenez R, Pedraza T, Baldoma L, Aguilar J, Badia J

机构信息

Department of Biochemistry, School of Pharmacy, University of Barcelona, 08028 Barcelona, Spain.

出版信息

J Bacteriol. 2000 Aug;182(16):4625-7. doi: 10.1128/JB.182.16.4625-4627.2000.

DOI:10.1128/JB.182.16.4625-4627.2000
PMID:10913097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC94635/
Abstract

Genes yiaP and yiaR of the yiaKLMNOPQRS cluster of Escherichia coli are required for the metabolism of the endogenously formed L-xylulose, whereas yiaS is required for this metabolism only in araD mutants. Like AraD, YiaS was shown to have L-ribulose-5-phosphate 4-epimerase activity. Similarity of YiaR to several 3-epimerases suggested that this protein could catalyze the conversion of L-xylulose-5-phosphate into L-ribulose-5-phosphate, thus completing the pathway between L-xylulose and the general metabolism.

摘要

大肠杆菌yiaKLMNOPQRS基因簇中的yiaP和yiaR基因是内源性生成的L-木酮糖代谢所必需的，而yiaS仅在araD突变体中参与该代谢过程。与AraD一样，YiaS被证明具有L-核糖-5-磷酸4-差向异构酶活性。YiaR与几种3-差向异构酶的相似性表明，该蛋白可以催化L-木酮糖-5-磷酸转化为L-核糖-5-磷酸，从而完成L-木酮糖与一般代谢之间的途径。

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引用本文的文献

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The gene yjfQ encodes the repressor of the yjfR-X regulon (ula), which is involved in L-ascorbate metabolism in Escherichia coli.基因yjfQ编码yjfR-X操纵子（ula）的阻遏物，该操纵子参与大肠杆菌中的L-抗坏血酸代谢。
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