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The gene yjfQ encodes the repressor of the yjfR-X regulon (ula), which is involved in L-ascorbate metabolism in Escherichia coli.基因yjfQ编码yjfR-X操纵子（ula）的阻遏物，该操纵子参与大肠杆菌中的L-抗坏血酸代谢。
J Bacteriol. 2002 Nov;184(21):6065-8. doi: 10.1128/JB.184.21.6065-6068.2002.
2
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4
The yiaKLX1X2PQRS and ulaABCDEFG gene systems are required for the aerobic utilization of L-ascorbate in Klebsiella pneumoniae strain 13882 with L-ascorbate-6-phosphate as the inducer.以6-磷酸-L-抗坏血酸作为诱导剂时，肺炎克雷伯菌13882菌株有氧利用L-抗坏血酸需要yiaKLX1X2PQRS和ulaABCDEFG基因系统。
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6
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.大肠杆菌中参与L-抗坏血酸异化作用的反向ulaG和ulaABCDEF操纵子表达的调控
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7
The ascorbate transporter of Escherichia coli.大肠杆菌的抗坏血酸转运蛋白。
J Bacteriol. 2003 Apr;185(7):2243-50. doi: 10.1128/JB.185.7.2243-2250.2003.

本文引用的文献

1
Utilization of L-ascorbate by Escherichia coli K-12: assignments of functions to products of the yjf-sga and yia-sgb operons.大肠杆菌K-12对L-抗坏血酸盐的利用：yjf-sga和yia-sgb操纵子产物的功能分配
J Bacteriol. 2002 Jan;184(1):302-6. doi: 10.1128/JB.184.1.302-306.2002.
2
Role of the yiaR and yiaS genes of Escherichia coli in metabolism of endogenously formed L-xylulose.大肠杆菌的yiaR和yiaS基因在内源性生成的L-木酮糖代谢中的作用。
J Bacteriol. 2000 Aug;182(16):4625-7. doi: 10.1128/JB.182.16.4625-4627.2000.
3
Regulation of expression of the yiaKLMNOPQRS operon for carbohydrate utilization in Escherichia coli: involvement of the main transcriptional factors.大肠杆菌中用于碳水化合物利用的yiaKLMNOPQRS操纵子表达的调控：主要转录因子的作用
J Bacteriol. 2000 Aug;182(16):4617-24. doi: 10.1128/JB.182.16.4617-4624.2000.
4
A rare 920-kilobase chromosomal inversion mediated by IS1 transposition causes constitutive expression of the yiaK-S operon for carbohydrate utilization in Escherichia coli.
J Biol Chem. 1998 Apr 3;273(14):8376-81. doi: 10.1074/jbc.273.14.8376.
5
The complete genome sequence of Escherichia coli K-12.大肠杆菌K-12的全基因组序列。
Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
6
Is the ribulose monophosphate pathway widely distributed in bacteria?磷酸戊糖途径在细菌中分布广泛吗？
Microbiology (Reading). 1997 Aug;143 ( Pt 8):2519-2520. doi: 10.1099/00221287-143-8-2519.
7
Novel phosphotransferase genes revealed by bacterial genome sequencing: a gene cluster encoding a putative N-acetylgalactosamine metabolic pathway in Escherichia coli.通过细菌基因组测序揭示的新型磷酸转移酶基因：大肠杆菌中一个编码假定的N-乙酰半乳糖胺代谢途径的基因簇。
Microbiology (Reading). 1996 Feb;142 ( Pt 2):231-250. doi: 10.1099/13500872-142-2-231.
8
Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes.大肠杆菌基因组分析。V. 76.0至81.5分钟区域的DNA序列。
Nucleic Acids Res. 1994 Jul 11;22(13):2576-86. doi: 10.1093/nar/22.13.2576.
9
Activation of a cryptic gene encoding a kinase for L-xylulose opens a new pathway for the utilization of L-lyxose by Escherichia coli.编码L-木酮糖激酶的隐性基因的激活为大肠杆菌利用L-来苏糖开辟了一条新途径。
J Biol Chem. 1994 Nov 25;269(47):29665-9.
10
New Tn10 derivatives for transposon mutagenesis and for construction of lacZ operon fusions by transposition.用于转座子诱变及通过转座构建lacZ操纵子融合体的新型Tn10衍生物。
Gene. 1984 Dec;32(3):369-79. doi: 10.1016/0378-1119(84)90012-x.

基因yjfQ编码yjfR-X操纵子（ula）的阻遏物，该操纵子参与大肠杆菌中的L-抗坏血酸代谢。

The gene yjfQ encodes the repressor of the yjfR-X regulon (ula), which is involved in L-ascorbate metabolism in Escherichia coli.

作者信息

Campos Evangelina, Aguilar Juan, Baldoma Laura, Badia Josefa

机构信息

Department of Biochemistry, Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain.

出版信息

J Bacteriol. 2002 Nov;184(21):6065-8. doi: 10.1128/JB.184.21.6065-6068.2002.

DOI:10.1128/JB.184.21.6065-6068.2002
PMID:12374842
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC135402/
Abstract

Mutations in yjfQ allowed us to identify this gene as the regulator of the operon yjfS-X (ula operon), reported to be involved in L-ascorbate metabolism. Inactivation of this gene renders constitutive the expression of the ula operon, indicating that YjfQ acts as a repressor. We also demonstrate that this repressor regulates the nearby yjfR gene, which in this way constitutes a regulon with the ula operon.

摘要

yjfQ基因的突变使我们能够将该基因鉴定为yjfS-X操纵子（ula操纵子）的调节因子，据报道该操纵子参与L-抗坏血酸代谢。该基因的失活导致ula操纵子的表达组成型，表明YjfQ作为阻遏物发挥作用。我们还证明，这种阻遏物调节附近的yjfR基因，从而与ula操纵子构成一个调控子。