早期线性生长迟缓与后期血压
Early linear growth retardation and later blood pressure.
作者信息
Gaskin P S, Walker S P, Forrester T E, Grantham-McGregor S M
机构信息
Tropical Metabolism Research Unit, University of the West Indies, Jamaica.
出版信息
Eur J Clin Nutr. 2000 Jul;54(7):563-7. doi: 10.1038/sj.ejcn.1601057.
OBJECTIVE
To examine the effects of stunting in early childhood on blood pressure in later childhood.
DESIGN
A cohort study.
SETTING
Kingston, Jamaica.
SUBJECTS
Seven to eight year old children, 120 stunted (height for age <-2 s.d. of the NCHS references) and 224 non-stunted (height for age >-1 s.d. of the NCHS references) at age 9-24 months.
METHODS
Stunted and non-stunted children were identified at age 9-24 months by house to-house survey of poor neighbourhoods in Kingston, Jamaica. Blood pressure and anthropometry were measured at age 7-8 y. Birth weight was obtained from hospital records (73%) or maternal recall.
RESULTS
The stunted children remained shorter and thinner than the non-stunted ones. In multiple regression analysis adjusting for size and pulse rate, the stunted children had higher systolic blood pressure (P<0.05). Birth weight was not a significant predictor of systolic blood pressure.
CONCLUSION
Stunting in early childhood may increase the risk of elevated systolic blood pressure in later life.
SPONSORSHIP
Nutricia Research Foundation, The Netherlands and the Commonwealth Caribbean Medical Research Council.
目的
研究儿童早期发育迟缓对儿童后期血压的影响。
设计
队列研究。
地点
牙买加金斯敦。
研究对象
9至24个月大时发育迟缓（身高低于美国国家卫生统计中心参考标准年龄别身高-2标准差）的7至8岁儿童120名，以及发育正常（身高高于美国国家卫生统计中心参考标准年龄别身高-1标准差）的224名。
方法
通过对牙买加金斯敦贫困社区挨家挨户调查，确定9至24个月大时发育迟缓及发育正常的儿童。在7至8岁时测量血压和人体测量数据。出生体重从医院记录（73%）或母亲回忆中获取。
结果
发育迟缓儿童比发育正常儿童更矮更瘦。在对身高和脉搏率进行校正的多元回归分析中，发育迟缓儿童的收缩压更高（P<0.05）。出生体重不是收缩压的显著预测因素。
结论
儿童早期发育迟缓可能会增加日后收缩压升高的风险。
资助
荷兰纽迪希亚研究基金会以及英联邦加勒比医学研究理事会。
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