• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

7,12-二甲基苯并(a)蒽的3,4-二氢二醇在小鼠皮肤中的强效肿瘤起始活性。

Potent tumor-initiating activity of the 3,4-dihydrodiol of 7,12-dimethylbenz(a)anthracene in mouse skin.

作者信息

Slaga T J, Gleason G L, DiGiovanni J, Sukumaran K B, Harvey R G

出版信息

Cancer Res. 1979 Jun;39(6 Pt 1):1934-6.

PMID:109189
Abstract

The abilities of the racemic trans-3,4-, 5,6-, and 8,9-dihydrodiols of 7,12-dimethylbenz(a)anthracene to initiate skin tumors in mice were determined by using a two-stage system of tumorigenesis. The 7,12-dimethylbenz(a)anthracene trans-3,4-dihydrodiol was found to be much more active as a tumor initiator than the parent hydrocarbon. The 7,12-dimethylbenz(a)anthracene trans-5,6- and 8,9-dihydrodiols were essentially inactive as skin tumor initiators. Our results suggest that the 3,4-dihydrodiol of 7,12-dimethylbenz(a)anthracene is a proximal carcinogen and that the "bay region" diol-epoxide may be the ultimate carcinogenic form of DMBA.

摘要

通过使用两阶段肿瘤发生系统，测定了7,12-二甲基苯并(a)蒽的外消旋反式-3,4-、5,6-和8,9-二氢二醇诱发小鼠皮肤肿瘤的能力。发现7,12-二甲基苯并(a)蒽反式-3,4-二氢二醇作为肿瘤引发剂比母体烃更具活性。7,12-二甲基苯并(a)蒽反式-5,6-和8,9-二氢二醇作为皮肤肿瘤引发剂基本无活性。我们的结果表明，7,12-二甲基苯并(a)蒽的3,4-二氢二醇是一种近端致癌物，并且“湾区”二醇环氧化物可能是DMBA的最终致癌形式。

相似文献

1
Potent tumor-initiating activity of the 3,4-dihydrodiol of 7,12-dimethylbenz(a)anthracene in mouse skin.7,12-二甲基苯并(a)蒽的3,4-二氢二醇在小鼠皮肤中的强效肿瘤起始活性。
Cancer Res. 1979 Jun;39(6 Pt 1):1934-6.
2
Mouse skin tumor-initiating activity of 5-, 7-, and 12-methyl- and fluorine-substituted benz[a]anthracenes.5-、7-和12-甲基及氟取代苯并[a]蒽的小鼠皮肤肿瘤起始活性。
J Natl Cancer Inst. 1982 Sep;69(3):725-8.
3
Carcinogenicity and mutagenicity of benz(a)anthracene diols and diol-epoxides.苯并(a)蒽二醇及二醇环氧化物的致癌性和致突变性。
Cancer Res. 1978 Jun;38(6):1699-704.
4
Oxidation of the trans-3,4-dihydrodiol metabolites of the potent carcinogen 7,12-dimethylbenz(a)anthracene and other benz(a)anthracene derivatives by 3 alpha-hydroxysteroid-dihydrodiol dehydrogenase: effects of methyl substitution on velocity and stereochemical course of trans-dihydrodiol oxidation.强效致癌物7,12-二甲基苯并(a)蒽及其他苯并(a)蒽衍生物的反式-3,4-二氢二醇代谢物被3α-羟基类固醇-二氢二醇脱氢酶氧化：甲基取代对反式二氢二醇氧化速度和立体化学过程的影响。
Cancer Res. 1988 Mar 1;48(5):1227-32.
5
The importance of the "bay region" diol-epoxide in 7,12-dimethylbenz[a]anthracene skin tumor initiation and mutagenesis.“湾区”二醇环氧化物在7,12-二甲基苯并[a]蒽诱发皮肤肿瘤及致突变过程中的重要性。
Cancer Lett. 1979 Apr;6(4-5):213-20. doi: 10.1016/s0304-3835(79)80036-1.
6
Mutagenicity and tumor-initiating activity of fluorinated derivatives of 7,12-dimethylbenz(a)anthracene.7,12-二甲基苯并(a)蒽的氟化衍生物的致突变性和肿瘤起始活性。
Cancer Res. 1979 Feb;39(2 Pt 1):411-4.
7
Both (+/-)syn- and (+/-)anti-7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxides initiate tumors in mouse skin that possess -CAA- to -CTA- mutations at Codon 61 of c-H-ras.（±）顺式和（±）反式-7,12-二甲基苯并[a]蒽-3,4-二醇-1,2-环氧化物均可在小鼠皮肤中引发肿瘤，这些肿瘤在c-H-ras基因第61密码子处存在从-CAA-到-CTA-的突变。
Cancer Res. 2000 Oct 15;60(20):5688-95.
8
High tumorigenicity of the 3,4-dihydrodiol of 7-methylbenz[c]acridine on mouse skin and in newborn mice.7-甲基苯并[c]吖啶的3,4-二氢二醇对小鼠皮肤和新生小鼠具有高致瘤性。
Cancer Res. 1986 Sep;46(9):4552-5.
9
A course of very small doses of DMBA, each of them allegedly with no promoting potency, acts with clear synergistic effect as a strong promoter of DMBA-initiated mouse skin carcinogenesis. A comparison of the tumorigenic and carcinogenic effects of DMBA (7,12-dimethylbenz-alpha-anthracene) and TPA (12-O-tetradecanoyl-phorbol-13-acetate) used as initiators and promoters in classical two-stage experimental protocols.一系列非常小剂量的二甲基苯并蒽（DMBA），据称每剂都没有促癌能力，但作为DMBA引发的小鼠皮肤癌发生的强力促进剂却具有明显的协同作用。比较了在经典的两阶段实验方案中用作引发剂和促进剂的二甲基苯并蒽（7,12 - 二甲基苯并-α-蒽，DMBA）和十四酰佛波醇乙酯（TPA）的致瘤和致癌作用。
APMIS Suppl. 1994;41:1-38.
10
Inhibition of the tumor-initiating ability of the potent carcinogen 7,12-dimethylbenz(a)anthracene by the weak tumor initiator 1,2,3,4-dibenzanthracene.弱致癌剂1,2,3,4-二苯并蒽对强致癌剂7,12-二甲基苯并(a)蒽的肿瘤起始能力的抑制作用。
Cancer Res. 1977 Jan;37(1):128-33.

引用本文的文献

1
Combined deletion of p38γ and p38δ reduces skin inflammation and protects from carcinogenesis.p38γ和p38δ的联合缺失可减轻皮肤炎症并预防癌症发生。
Oncotarget. 2015 May 30;6(15):12920-35. doi: 10.18632/oncotarget.4320.
2
The molecular etiology and prevention of estrogen-initiated cancers: Ockham's Razor: Pluralitas non est ponenda sine necessitate. Plurality should not be posited without necessity.雌激素引发癌症的分子病因学与预防：奥卡姆剃刀原理：若无必要，勿增实体。
Mol Aspects Med. 2014 Apr;36:1-55. doi: 10.1016/j.mam.2013.08.002. Epub 2013 Aug 30.
3
Langerhans cells facilitate epithelial DNA damage and squamous cell carcinoma.
朗格汉斯细胞促进上皮细胞 DNA 损伤和鳞状细胞癌的发生。
Science. 2012 Jan 6;335(6064):104-8. doi: 10.1126/science.1211600.
4
Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis.Stat3的破坏揭示了其在上皮癌发生的起始和促进阶段中的关键作用。
J Clin Invest. 2004 Sep;114(5):720-8. doi: 10.1172/JCI21032.
5
Relating aromatic hydrocarbon-induced DNA adducts and c-H-ras mutations in mouse skin papillomas: the role of apurinic sites.芳香烃诱导的小鼠皮肤乳头状瘤中的DNA加合物与c-H-ras突变的关系：脱嘌呤位点的作用。
Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10422-6. doi: 10.1073/pnas.92.22.10422.
6
Polycyclic aromatic hydrocarbons and possible metabolites: convertogenic activity in yeast and tumor initiating activity in mouse skin.多环芳烃及其可能的代谢产物：在酵母中的转化活性及在小鼠皮肤中的肿瘤起始活性。
J Cancer Res Clin Oncol. 1981;102(2):127-39. doi: 10.1007/BF00410664.
7
Metabolism of 7,12-dimethylbenzanthracene (DMBA) by mouse skin keratinocytes, fibroblasts, and carcinoma cells in culture.培养的小鼠皮肤角质形成细胞、成纤维细胞和癌细胞对7,12-二甲基苯并蒽（DMBA）的代谢。
Arch Toxicol. 1980 Mar;44(1-3):181-95. doi: 10.1007/BF00303195.
8
Differentiation of the mammary gland and susceptibility to carcinogenesis.乳腺的分化与致癌易感性。
Breast Cancer Res Treat. 1982;2(1):5-73. doi: 10.1007/BF01805718.
9
Metabolism and activation of chemical carcinogens.化学致癌物的代谢与活化
Mol Cell Biochem. 1980 Sep 15;32(2):95-104. doi: 10.1007/BF00227802.
10
SENCAR mouse skin tumorigenesis model versus other strains and stocks of mice.SENCAR小鼠皮肤肿瘤发生模型与其他品系和种群的小鼠对比
Environ Health Perspect. 1986 Sep;68:27-32. doi: 10.1289/ehp.866827.