Kuang Y, Zhang Z, Zhang X
Surgery Department, First Affiliated Hospital, Suzhou Medical College.
Zhonghua Zhong Liu Za Zhi. 1998 Jul;20(4):305-7.
To study interleukin-6(IL-6) and its receptors in human breast cancer.
Using ELISA method and ABC immunohistochemistry, IL-6 and its receptors were examined in 45 cases of breast cancer, 10 cases of benign breast diseases and 17 cases of healthy women.
High levels of serum IL-6 and its soluble receptors were frequently observed in breast cancer patients. The levels correlated with the stage and axillary lymph node involvement. The positive staining of IL-6, IL-6R alpha, gp130 were 68.9% in neoplasm tissue.
IL-6 and its soluble receptors may be important paramenters reflecting the biological behaviour and prognosis of breast cancer.
研究白细胞介素-6（IL-6）及其受体在人类乳腺癌中的情况。
采用酶联免疫吸附测定（ELISA）法和ABC免疫组织化学法，检测45例乳腺癌患者、10例乳腺良性疾病患者及17例健康女性体内的IL-6及其受体。
乳腺癌患者血清中IL-6及其可溶性受体水平常升高。这些水平与分期及腋窝淋巴结受累情况相关。肿瘤组织中IL-6、IL-6Rα、gp130的阳性染色率为68.9%。
IL-6及其可溶性受体可能是反映乳腺癌生物学行为和预后的重要参数。
