Riede U N, Schmitz E, Robausch T h, Kiefer G, Grünholz D, Sandritter W
Beitr Pathol. 1975;154(2):140-60.
Thyroid hormoned influence the quantitative cytoarchitecture of hepatocytes by stimulating the membrane synthesis of mitochondria and ergastoplasm. The cellular and nuclear changes produced by thyroidectomy were analysed cytophotometrically and morphometrically.
21 days after thyroidectomy the liver tissues of 10 male Wistar rats were examined. 5 sham-operated animals served as controls. All rats received Altromin-R-standard diet. The cytophotometric analysis is based on the method described by Sandritter. The morphometric study was carried out following Weibel's methods.
As a consequence of the changed cellular metabolism, smaller hepatocytes and nuclei (but larger nucleoli) are found in the hypothyroid rats. As compared with controls, hepatocytes hardly show tetraploid nuclei, which is due to inhibited polyploidisation. The mitochondrial content has become considerably smaller in the hypothyroid hepatocytes. The cristal membranes, the mitochondrial and peroxysomal volume per hepatocyte show a similar reaction pattern, which is considered to be a sign of reduced cellular metabolism. The volume loss of the ergastoplasm confirms this assumption.
甲状腺激素通过刺激线粒体和内质网的膜合成来影响肝细胞的定量细胞结构。对甲状腺切除术后产生的细胞和细胞核变化进行了细胞光度测定和形态测定分析。
在甲状腺切除术后21天，对10只雄性Wistar大鼠的肝脏组织进行检查。5只假手术动物作为对照。所有大鼠均给予Altromin - R标准饮食。细胞光度测定分析基于桑德里特描述的方法。形态测定研究按照魏贝尔的方法进行。
由于细胞代谢改变，甲状腺功能减退的大鼠肝细胞和细胞核较小（但核仁较大）。与对照组相比，肝细胞几乎没有四倍体细胞核，这是由于多倍体化受到抑制。甲状腺功能减退的肝细胞中线粒体含量显著减少。嵴膜、每个肝细胞的线粒体和过氧化物酶体体积呈现相似的反应模式，这被认为是细胞代谢降低的迹象。内质网体积的减少证实了这一假设。
