Kyrmizakis Dionysios E, Pangalos Aris, Papadakis Chariton E, Logothetis John, Maroudias Nicolas J, Helidonis Emmanuel S
Department of Otolaryngology, University of Crete School of Medicine, Heraklion, Crete, Greece.
J Oral Maxillofac Surg. 2004 Jul;62(7):840-4. doi: 10.1016/j.joms.2003.09.015.
We sought to investigate the efficacy of botulinum toxin type A in the treatment of Frey and crocodile tears syndromes. Frey syndrome is a common complication after surgical intervention or injury in the region of the parotid gland. Crocodile tears syndrome is unusual and manifests after facial nerve paralysis and other causes such as head trauma.
This was a prospective nonrandomized, nonblinded study. We used botulinum toxin type A for the treatment of 11 patients with gustatory sweating and 2 patients with crocodile tears syndrome.
The follow-up (6 to 23 months) of patients with gustatory sweating syndrome showed complete absence of sweating in the affected regions. One patient had recurrence after 16 months and was retreated successfully. At 1 and 24 weeks after treatment of the patients with the crocodile tears syndrome, the Schirmer test showed a reduction of stimulated lacrimation on the impaired side approaching the normal values of the unaffected side.
Our study supports the widely accepted aspect that botulinum toxin type A could be the treatment of choice for gustatory sweating syndrome. We also propose the toxin as a valuable treatment for crocodile tears syndrome.
我们试图研究A型肉毒杆菌毒素治疗味觉性出汗综合征和鳄鱼泪综合征的疗效。味觉性出汗综合征是腮腺区域手术干预或损伤后常见的并发症。鳄鱼泪综合征较为罕见，在面神经麻痹及其他原因（如头部外伤）后出现。
这是一项前瞻性非随机、非盲法研究。我们使用A型肉毒杆菌毒素治疗11例味觉性出汗患者和2例鳄鱼泪综合征患者。
味觉性出汗综合征患者随访（6至23个月）显示，受累区域完全不出汗。1例患者在16个月后复发，再次治疗成功。鳄鱼泪综合征患者治疗后1周和24周时，泪液分泌试验显示患侧刺激流泪减少，接近未受累侧的正常值。
我们的研究支持广泛认可的观点，即A型肉毒杆菌毒素可能是味觉性出汗综合征的首选治疗方法。我们还提出该毒素是治疗鳄鱼泪综合征的一种有效方法。
