Waldmann H
Immunology. 1975 Mar;28(3):497-507.
Evidence is presented which suggests that T cell-dependent nonspecific factor (NSF) cannot be the sole mediator of 'co-operation' for all types of thymus-dependent antibody response. NSF can replace the requirement for T cells in responses to hapten conjugated to particulate carriers, but cannot do so in responses to hapten conjugates of soluble thymus-dependent carriers.
现有证据表明,T细胞依赖性非特异性因子(NSF)不可能是所有类型胸腺依赖性抗体应答中“协作”的唯一介导因子。NSF能够替代对T细胞的需求,以应对与颗粒性载体偶联的半抗原,但在针对可溶性胸腺依赖性载体的半抗原偶联物的应答中则无法做到这一点。