• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Antigen-specific T-helper cells stimulate H-2-compatible and H-2-incompatible B-cell blasts polyclonally.抗原特异性辅助性T细胞可多克隆地刺激H-2相容和H-2不相容的B细胞母细胞。
J Exp Med. 1980 Jan 1;151(1):194-203. doi: 10.1084/jem.151.1.194.
2
Frequencies of mitogen-reactive B cells in the mouse. II. Frequencies of B cells producing antibodies which lyse sheep or horse erythrocytes, and trinitrophenylated or nitroiodophenylated sheep erythrocytes.小鼠中有丝分裂原反应性B细胞的频率。II. 产生能裂解绵羊或马红细胞以及三硝基苯基化或硝基碘苯基化绵羊红细胞的抗体的B细胞频率。
J Exp Med. 1977 Jun 1;145(6):1520-30. doi: 10.1084/jem.145.6.1520.
3
The purified protein derivative of turberculin, a B-cell mitogen that distinguishes in its action resting, small B cells from activated B-cell blasts.结核菌素纯蛋白衍生物，一种B细胞有丝分裂原，其作用能区分静止的小B细胞与活化的B细胞母细胞。
J Exp Med. 1979 Dec 1;150(6):1339-50. doi: 10.1084/jem.150.6.1339.
4
Mitogen-activated B-cell blasts reactive to more than one mitogen.对一种以上有丝分裂原产生反应的有丝分裂原激活的B细胞母细胞。
J Exp Med. 1979 Mar 1;149(3):553-64. doi: 10.1084/jem.149.3.553.
5
Cellular interaction and the environment in lymphocyte development: the roles of antigen, histocompatibility, and growth factors in T cell-dependent B cell stimulation.淋巴细胞发育中的细胞相互作用与环境：抗原、组织相容性和生长因子在T细胞依赖性B细胞刺激中的作用。
Prog Clin Biol Res. 1981;66 Pt A:579-88.
6
T-cell-dependent B-cell stimulation is H-2 restricted and antigen dependent only at the resting B-cell level.T细胞依赖性B细胞刺激是H-2限制性的，并且仅在静止B细胞水平上依赖抗原。
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1612-6. doi: 10.1073/pnas.77.3.1612.
7
Functional characteristics of Peyer's patch lymphoid cells. II. Lipopolysaccharide is thymus dependent.派尔集合淋巴结淋巴细胞的功能特性。II. 脂多糖依赖胸腺。
J Exp Med. 1974 Feb 1;139(2):407-13. doi: 10.1084/jem.139.2.407.
8
Clonal induction of helper T cells: conversion of specific signals into nonspecific signals.辅助性T细胞的克隆诱导：将特异性信号转化为非特异性信号。
Int Arch Allergy Appl Immunol. 1980;61(2):227-37. doi: 10.1159/000232437.
9
Carrier-directed anti-hapten responses by B-cell subsets.B细胞亚群介导的针对半抗原的载体导向性应答。
J Exp Med. 1977 Jul 1;146(1):1-10. doi: 10.1084/jem.146.1.1.
10
Frequency analysis of immunoglobulin V-gene expression and functional reactivities in bone marrow B cells.骨髓B细胞中免疫球蛋白V基因表达及功能反应性的频率分析
J Immunol. 1981 Mar;126(3):887-90.

引用本文的文献

1
In vivo activation of mouse spleen lymphocytes by lipid A in carrier-free form.无载体形式的脂多糖对小鼠脾淋巴细胞的体内激活作用。
Immunology. 1982 Feb;45(2):333-40.
2
B-cell growth factor: distinction from T-cell growth factor and B-cell maturation factor.B细胞生长因子：与T细胞生长因子和B细胞成熟因子的区别。
Proc Natl Acad Sci U S A. 1982 Dec;79(23):7455-9. doi: 10.1073/pnas.79.23.7455.
3
T-cell regulation of pokeweed-mitogen-induced polyclonal immunoglobulin production in mice. I. Characterization of helper T cells.小鼠中T细胞对商陆丝裂原诱导的多克隆免疫球蛋白产生的调节。I. 辅助性T细胞的特性
Immunology. 1982 Jul;46(3):575-81.
4
Dissociation of two signals required for activation of resting B cells.静止B细胞激活所需的两种信号的解离。
Proc Natl Acad Sci U S A. 1982 Mar;79(6):1989-93. doi: 10.1073/pnas.79.6.1989.
5
Human anti-tetanus antibody response in vitro: autologous and allogeneic T cells provide help by different routes.人抗破伤风抗体的体外应答：自体和异体T细胞通过不同途径提供辅助。
Clin Exp Immunol. 1981 Oct;46(1):171-7.
6
T-cell-dependent B-cell stimulation is H-2 restricted and antigen dependent only at the resting B-cell level.T细胞依赖性B细胞刺激是H-2限制性的，并且仅在静止B细胞水平上依赖抗原。
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1612-6. doi: 10.1073/pnas.77.3.1612.
7
Multiple pathways of T-T interaction in the generation of cytotoxic T lymphocytes to alloantigens.细胞毒性T淋巴细胞针对同种异体抗原产生过程中T-T相互作用的多种途径。
J Exp Med. 1980 May 1;151(5):1125-38. doi: 10.1084/jem.151.5.1125.
8
Mediators from cloned T helper cell lines affect immunoglobulin expression by B cells.来自克隆的辅助性T细胞系的介质影响B细胞的免疫球蛋白表达。
Proc Natl Acad Sci U S A. 1982 Aug;79(15):4756-60. doi: 10.1073/pnas.79.15.4756.
9
T cell-dependent activation of resting B cells: requirement for both nonspecific unrestricted and antigen-specific Ia-restricted soluble factors.静止B细胞的T细胞依赖性激活：对非特异性无限制和抗原特异性Ia限制可溶性因子的需求。
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2497-501. doi: 10.1073/pnas.78.4.2497.
10
Quantitative studies on T cell diversity. I. Determination of the precursor frequencies for two types of streptococcus A-specific helper cells in nonimmune, polyclonally activated splenic T cells.T细胞多样性的定量研究。I. 非免疫、多克隆激活的脾T细胞中两种A群链球菌特异性辅助细胞前体频率的测定。
J Exp Med. 1980 Sep 1;152(3):477-92. doi: 10.1084/jem.152.3.477.

本文引用的文献

1
The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation.对半抗原-蛋白质偶联物二次应答中的载体效应。II. 细胞协作。
Eur J Immunol. 1971 Jan;1(1):18-27. doi: 10.1002/eji.1830010104.
2
A requirement for two cell types for antibody formation in vitro.体外抗体形成需要两种细胞类型。
Science. 1967 Dec 22;158(3808):1573-5. doi: 10.1126/science.158.3808.1573.
3
Separation of cells by velocity sedimentation.通过速度沉降法分离细胞。
J Cell Physiol. 1969 Jun;73(3):191-201. doi: 10.1002/jcp.1040730305.
4
Induction of a hemolysin response in vitro. Interaction of cells of bone marrow origin and thymic origin.体外溶血素反应的诱导。骨髓来源细胞与胸腺来源细胞的相互作用。
J Exp Med. 1970 Dec 1;132(6):1267-78. doi: 10.1084/jem.132.6.1267.
5
Thymus and antigen-reactive cells.胸腺与抗原反应性细胞。
Transplant Rev. 1969;1:3-42. doi: 10.1111/j.1600-065x.1969.tb00135.x.
6
Immunoglobulins as cell receptors.作为细胞受体的免疫球蛋白。
Ann N Y Acad Sci. 1971 Dec 31;190:420-31. doi: 10.1111/j.1749-6632.1971.tb13552.x.
7
Cell components in the immune response. IV. Relationships and possible interactions.免疫反应中的细胞成分。IV. 关系及可能的相互作用。
Cell Immunol. 1970 Jul;1(2):196-206. doi: 10.1016/0008-8749(70)90007-9.
8
Increase in intracellular immunoglobulins in the majority of splenic lymphoid cells after primary immunization.初次免疫后多数脾淋巴细胞内免疫球蛋白增加。
Eur J Immunol. 1974 Feb;4(2):138-45. doi: 10.1002/eji.1830040214.
9
Response of mouse T and B lymphocytes to sheep erythrocytes.小鼠T淋巴细胞和B淋巴细胞对绵羊红细胞的反应。
Nat New Biol. 1972 Jan 26;235(56):115-8. doi: 10.1038/newbio235115a0.
10
Letter: T cell-dependent mediator in the immune response.信件：免疫反应中T细胞依赖性介质。
Nature. 1973 Jun 8;243(5406):356-7. doi: 10.1038/243356a0.

抗原特异性辅助性T细胞可多克隆地刺激H-2相容和H-2不相容的B细胞母细胞。

Antigen-specific T-helper cells stimulate H-2-compatible and H-2-incompatible B-cell blasts polyclonally.

作者信息

Schreier M H, Andersson J, Lernhardt W, Melchers F

出版信息

J Exp Med. 1980 Jan 1;151(1):194-203. doi: 10.1084/jem.151.1.194.

DOI:10.1084/jem.151.1.194
PMID:6965306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2185768/
Abstract

Lipopolysaccharide (LPS)-activated B-cell blasts from C57BL/6J nu/nu spleen cells develop into IgM-secreting clones after stimulation by antigen-specific T-helper cells of C57BL/6J origin. Although induction of help is antigen-dependent, help itself acts polyclonally. 1 of 1--3 B-cell blasts is restimulated in a homologous fashion by LPS, or in a heterologous fashion by sheep erythrocyte (SRC)- or horse erythrocyte (HRC)-activated T-helper cells. The repertoire of activated B-cell blasts reflects the polyclonal nature of activation: approximately 1 in 1,000--3,000 restimulated B-cell blasts is specific for SRC, 1 in 300--1,000 is specific for HRC, and 1 in 100--300 specific for trinitrophenylated SRC (TNP30-SRC). B-cell blasts that are either H-2 compatible or H-2 incompatible with the antigen-activated T-cell help are stimulated polyclonally in similar high frequencies. Thus, neither antigen nor H-2 compatibility are required to stimulate a B-cell blast into the next cell cycle.

摘要

来自C57BL/6J裸鼠脾脏细胞的脂多糖（LPS）激活的B细胞母细胞，在受到C57BL/6J来源的抗原特异性辅助性T细胞刺激后，会发育成分泌IgM的克隆。虽然辅助作用的诱导依赖于抗原，但辅助作用本身具有多克隆性。1/1至3个B细胞母细胞以同源方式被LPS再次刺激，或以异源方式被绵羊红细胞（SRC）或马红细胞（HRC）激活的辅助性T细胞再次刺激。被激活的B细胞母细胞的库反映了激活的多克隆性质：在1000至3000个再次刺激的B细胞母细胞中，约1个对SRC特异，300至1000个中有1个对HRC特异，100至300个中有1个对三硝基苯化SRC（TNP30-SRC）特异。与抗原激活的T细胞辅助作用H-2相容或H-2不相容的B细胞母细胞，以相似的高频率被多克隆刺激。因此，无论是抗原还是H-2相容性，都不是刺激B细胞母细胞进入下一个细胞周期所必需的。