Holinger D P, Hill S A, Martin D L, Faux S F, Ives J R, Schomer D L
Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.
J Clin Neurophysiol. 2000 May;17(3):331-5. doi: 10.1097/00004691-200005000-00011.
The selection of which high-pass filter cutoff to use in P300 studies continues to be a serious methodological consideration. To determine whether there was an optimal range of bandpass widths-a range in which P300 voltage and latency would not show statistically significant differences-the authors recorded P300 responses to the auditory "oddball" paradigm from Cz and Pz electrodes in a group of eight healthy males. The authors used high-pass filter cutoffs of 0.01, 0.1, 0.3, and 1.0 Hz with low-pass filter cutoffs of 30 and 100 Hz and measured both P300 peak voltages and P300 integrated mean voltages at 12 bandpass settings. There were statistically significant differences in 7 out of 12 bandpass comparisons for P300 peak voltages and in 7 out of 12 bandwidth comparisons for P300 integrated mean voltages. For P300 latencies, there were statistically significant differences in 9 out of 12 bandwidth comparisons. Based on these results, the best recommendation, therefore, is that the high-pass filter be set no higher than 0.3 Hz.
在P300研究中，选择使用何种高通滤波器截止频率仍是一个重要的方法学考量因素。为了确定是否存在一个最佳的带通宽度范围（即P300电压和潜伏期在该范围内不会显示出统计学上的显著差异），作者在一组8名健康男性中记录了从Cz和Pz电极对听觉“oddball”范式的P300反应。作者使用了0.01、0.1、0.3和1.0 Hz的高通滤波器截止频率以及30和100 Hz的低通滤波器截止频率，并在12种带通设置下测量了P300峰值电压和P300积分平均电压。在P300峰值电压的12次带通比较中，有7次存在统计学上的显著差异；在P300积分平均电压的12次带宽比较中，有7次存在统计学上的显著差异。对于P300潜伏期，在12次带宽比较中有9次存在统计学上的显著差异。因此，基于这些结果，最佳建议是将高通滤波器设置不高于0.3 Hz。
