Troppmair J, Rapp U R
Institut f. Medizinische Strahlenkunde und Zellforschung (MSZ), Würzburg.
Zentralbl Chir. 2000;125 Suppl 1:12-5.
The analysis of the genetic causes of tumor development led to the identification of many genes affected in these diseases, which play a role in the control of cell proliferation and apoptosis. However, these studies also suggested that not all alterations are equal with regard to their effect on tumor growth, and they demonstrated that the deregulation of the classical cytoplasmic cascade made up by Ras-Raf-MEK and ERK plays a critical role in tumor development. These findings also raise the hope that via interference with a single pathway growth of a tumor carrying multiple genetic alterations will be affected.
对肿瘤发生的遗传原因进行分析后，发现了许多在这些疾病中受到影响的基因，它们在细胞增殖和凋亡的控制中发挥作用。然而，这些研究还表明，并非所有改变对肿瘤生长的影响都是相同的，并且它们证明由Ras-Raf-MEK和ERK组成的经典细胞质级联反应失调在肿瘤发生中起关键作用。这些发现也带来了一种希望，即通过干扰单一途径，携带多种基因改变的肿瘤生长将受到影响。
