Matalliotakis I, Koumantaki Y, Evageliou A, Matalliotakis G, Goumenou A, Koumantakis E
Department of Obstetrics and Gynecology, University Hospital, Heraklion, Crete, Greece.
Int J Fertil Womens Med. 2000 May-Jun;45(3):236-40.
To confirm the presence of L-carnitine in human seminal plasma, to show differences between L-carnitine concentrations in fertile and infertile subjects, and to show potential relationships between L-carnitine and semen quality.
Seminal plasma from 101 men obtained by masturbation was examined for the presence of L-carnitine. Semen samples were divided as follows: (a) in eight groups according to the etiology of fertility, (b) in two groups on the basis of normal or abnormal spermiogram, (c) correlation of the amount of L-carnitine in seminal plasma with values of the spermiogram.
We found the following: (1) L-carnitine levels differ significantly between controls and the patient groups (P < .0001) (2) The group with normal spermiogram has a mean value for L-carnitine of 478.4 while the abnormal one comes to 100.58. This difference is statistically significant (P < .0001). (3) There is a statistically significant, positive correlation between L-carnitine and the number of spermatozoa, the percentage of motile spermatozoa, and the percentage of normal forms (P < .0001).
These findings suggest that determination of seminal carnitine values might provide the physician with an additional means of evaluating the infertile male.
确认人体精浆中左旋肉碱的存在，揭示生育力正常和不育男性精浆中左旋肉碱浓度的差异，并表明左旋肉碱与精液质量之间的潜在关系。
对通过手淫获取的101名男性的精浆进行左旋肉碱检测。精液样本按以下方式分组：(a) 根据生育力病因分为八组；(b) 根据精子图谱正常或异常分为两组；(c) 精浆中左旋肉碱含量与精子图谱各项指标的相关性。
我们发现：(1) 对照组与患者组之间的左旋肉碱水平存在显著差异（P < 0.0001）；(2) 精子图谱正常组的左旋肉碱平均值为478.4，而异常组为100.58。这种差异具有统计学意义（P < 0.0001）；(3) 左旋肉碱与精子数量、活动精子百分比和正常形态精子百分比之间存在统计学上显著的正相关（P < 0.0001）。
这些发现表明，测定精浆中肉碱值可能为医生评估不育男性提供一种额外的手段。
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