精索静脉曲张所致不育少弱畸精子症男性精液中的左旋肉碱

Seminal L-Carnitine In Infertile Oligoasthenoteratozoospermic Men with Varicocele.

作者信息

Mostafa Taymour, Abougabal Khadiga, Mintziori Gesthimani, Nabil Nashaat, Adel Mohamed, AboSief Ahmed F

机构信息

Department of Andrology, Sexology & STIs, Faculty of Medicine, Cairo University, Cairo, Egypt.

Department of Clinical and Chemical Pathology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.

出版信息

J Reprod Infertil. 2022 Jan-Mar;23(1):26-32. doi: 10.18502/jri.v23i1.8449.

DOI:10.18502/jri.v23i1.8449

PMID:36045882

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9361723/

Abstract

BACKGROUND

Few studies have investigated the relationship of seminal L-Carnitine (LC) with male infertility associated with varicocele. The purpose of this prospective cross-sectional study was to assess seminal plasma LC levels in infertile oligoathenoteratozoospermic (OAT) men with varicocele.

METHODS

Overall, 86 men were investigated. They were divided into infertile OAT men with varicocele (n=45), infertile OAT men without varicocele (n=21), and fertile men (n=20) as a control group. According to WHO guidelines, these men were subjected to history taking, clinical examination, and semen analysis. Seminal LC levels were evaluated by the colorimetric method. Statistical comparisons were done using Kruskal-Wallis and Mann-Whitney U tests and correlations were verified by the Pearson test. P-value<0.05 was set to be statistically significant.

RESULTS

The mean seminal plasma LC levels were significantly lower in infertile OAT men with varicocele (216.3±57.1 ) compared to infertile OAT men without varicocele (252.9±62.9 , p=0.01), or fertile men (382.8±63.6 , p=0.001). Besides, the mean seminal plasma LC level exhibited statistically significant decreases in infertile OAT men of varicocele grade III compared to varicocele grade II cases, and in infertile OAT men with bilateral varicocele compared with unilateral varicocele cases. Collectively, there was a statistically significant positive correlation between seminal LC levels with sperm concentration, motility, and normal morphology.

CONCLUSION

Seminal LC levels are expressively reduced in infertile OAT men with varicocele and are influenced by an increase in varicocele grade and laterality.

摘要

背景

很少有研究调查精浆左旋肉碱（LC）与精索静脉曲张相关男性不育之间的关系。这项前瞻性横断面研究的目的是评估患有精索静脉曲张的少弱畸精子症（OAT）不育男性的精浆LC水平。

方法

总共对86名男性进行了调查。他们被分为患有精索静脉曲张的不育OAT男性（n = 45）、不患有精索静脉曲张的不育OAT男性（n = 21）以及作为对照组的生育男性（n = 20）。根据世界卫生组织的指南，对这些男性进行了病史采集、临床检查和精液分析。通过比色法评估精浆LC水平。使用Kruskal-Wallis检验和Mann-Whitney U检验进行统计比较，并通过Pearson检验验证相关性。设定P值<0.05具有统计学意义。

结果

与不患有精索静脉曲张的不育OAT男性（252.9±62.9，p = 0.01）或生育男性（382.8±63.6，p = 0.001）相比，患有精索静脉曲张的不育OAT男性的平均精浆LC水平显著降低（216.3±57.1）。此外，与II级精索静脉曲张病例相比，III级精索静脉曲张的不育OAT男性的平均精浆LC水平呈现出统计学上的显著降低，并且与单侧精索静脉曲张病例相比，双侧精索静脉曲张的不育OAT男性的平均精浆LC水平也显著降低。总体而言，精浆LC水平与精子浓度、活力和正常形态之间存在统计学上的显著正相关。