Osowiecki D M, Cohen R A, Morrow K M, Paul R H, Carpenter C C, Flanigan T, Boland R J
Department of Psychiatry and Human Behavior, Brown University Medical School, Providence Rhode Island, USA.
AIDS. 2000 Jul 7;14(10):1327-32. doi: 10.1097/00002030-200007070-00004.
The purpose of this study was to examine the impact of neurocognitive and emotional distress and immune system dysfunction on quality of life in women with HIV.
Thirty-six HIV-seropositive women were administered measures of mood status (Profile of Mood States), quality of life (Multidimensional Quality of Life Questionnaire for Persons with HIV) and cognitive function. CD4 cell counts were obtained as an indicator of immune system status.
Regression analyses revealed that independent of severity of emotional distress, neurocognitive deficits on measures of executive control and speed of information processing were associated with reduced quality of life. Emotional status also was associated with quality of life and together with neurocognitive performance accounted for most of the variance associated with quality of life. Reduced CD4 cell count was significantly associated with neurocognitive deficits, but not severity of emotional distress or quality of life.
Quality of life among women who are infected with HIV is strongly influenced by both neurocognitive and emotional status, as women with the greatest neurocognitive impairment and emotional distress report the poorest quality of life.
本研究旨在探讨神经认知和情绪困扰以及免疫系统功能障碍对感染HIV女性生活质量的影响。
对36名HIV血清阳性女性进行了情绪状态（情绪状态剖面图）、生活质量（HIV感染者多维生活质量问卷）和认知功能测量。获取CD4细胞计数作为免疫系统状态指标。
回归分析显示，与情绪困扰严重程度无关，执行控制和信息处理速度测量方面的神经认知缺陷与生活质量降低有关。情绪状态也与生活质量相关，并且与神经认知表现共同解释了与生活质量相关的大部分变异。CD4细胞计数降低与神经认知缺陷显著相关，但与情绪困扰严重程度或生活质量无关。
感染HIV的女性生活质量受到神经认知和情绪状态的强烈影响，因为神经认知损害和情绪困扰最严重的女性报告的生活质量最差。
