Anna A. Rubtsova, PhD, MA, MSc, is an Assistant Research Professor, Department of Behavioral Sciences and Health Education, Emory University Rollins School of Public Health, Atlanta, Georgia, USA. Samir Sabbag, MD, is an Assistant Professor, Department of Psychiatry, University of Miami, Miami, Florida, USA. Erin Sundermann, PhD, is an Assistant Project Scientist, Department of Psychiatry, University of California, San Diego, California, USA. Annie L. Nguyen, PhD, is an Assistant Professor, Department of Family Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA. Ronald J. Ellis, MD, PhD, is a Professor, Departments of Neuroscience and Psychiatry, University of California, San Diego, California, USA. David J. Moore, PhD, is an Associate Professor, Department of Psychiatry, University of California, San Diego, California, USA. Scott Letendre, MD, is a Professor, Department of Medicine, University of California, San Diego, California, USA. Dilip V. Jeste, MD, is a Distinguished Professor, Departments of Neuroscience and Psychiatry, University of California, San Diego, California, USA. María J. Marquine, PhD, is an Assistant Professor, Department of Psychiatry, University of California, San Diego, California, USA.
J Assoc Nurses AIDS Care. 2020 May-Jun;31(3):290-300. doi: 10.1097/JNC.0000000000000142.
Little is known about the effects of aging-related conditions on health-related quality of life (HRQOL) among people living with HIV (PLWH). The purpose of our study was to examine the independent effects of neurocognitive impairment (NCI) and frailty and the interactive effects with HIV serostatus on HRQOL. Our sample consisted of 121 adults (63 PLWH and 58 HIV-uninfected) participating in the Multi-Dimensional Successful Aging among HIV-Infected Adults study at the University of California, San Diego. HRQOL was measured with the Medical Outcome Study 36-Item Short Form Health Survey scale. We found that frailty was significantly associated with HRQOL (p < .001) in the overall sample, and this effect was significantly stronger for PLWH than HIV-uninfected adults. NCI was not significantly associated with HRQOL in our sample. Frailty may be a particularly important factor in HRQOL for PLWH, highlighting the need for prevention and intervention strategies to mitigate the risks for frailty.
对于老年相关疾病对艾滋病毒感染者（PLWH）的健康相关生活质量（HRQOL）的影响知之甚少。我们研究的目的是检查神经认知障碍（NCI）和脆弱与 HIV 阳性状态之间的相互作用对 HRQOL 的独立影响。我们的样本由 121 名成年人（63 名 PLWH 和 58 名 HIV 未感染者）组成，他们参加了加利福尼亚大学圣地亚哥分校的 HIV 感染者成人多维成功老龄化研究。HRQOL 采用医疗结局研究 36 项简明健康调查量表进行测量。我们发现，脆弱与整体样本中的 HRQOL 显著相关（p <.001），PLWH 的这一影响明显强于 HIV 未感染者。在我们的样本中，NCI 与 HRQOL 无显著相关性。脆弱可能是 PLWH HRQOL 的一个特别重要的因素，这凸显了需要预防和干预策略来减轻脆弱的风险。
